Gipuzkoa
In May 2006 the INMA project was set up in Gipuzkoa with the aim of evaluating the role of the environmental pollutants present in the air, water and diet in the growth and development of the children. The incorporation of the women to the cohort was made coinciding with the first echography of pregnancy control. Biological samples were taken (blood, urine, hair, placenta, etc.) and a series of questionnaires were complimented (general, diet, labour, environmental, etc.) to evaluate the impact of the environmental pollutants present in the air and the water of consumption, as well as an estimation of the polluting agents contributed by the diet.
The mothers were recruited from population visiting at the Hospital of Zumarraga, which includes the municipalities of the Goierri and the Alto and Medio Urola. They were selected of this area because of the characteristics of the services of the hospital and primary attention centre, as well as by the environmental characteristics: hard presence of metallurgical industry, high density of traffic, low levels of products derived from the disinfection in the consumption water and a rich diet in fish, together with certain degree of hypothyroidism in the pregnant women.
Since then, the pursuit of 640 women has been made in first and the third trimester of pregnancy. At the moment the pursuit is being made of 623 children in aspects of growth and neurobehavioural development.
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Funders of INMA-Gipuzkoa cohort:
This study was funded by grants from Instituto de Salud Carlos III (FIS-PI06/0867, FIS-PI09/00090, FIS-PI13/02187 and FIS-PI18/01142 incl. FEDER funds), CIBERESP, Department of Health of the Basque Government (2005111093, 2009111069, 2013111089 and 2015111065), and the Provincial Government of Gipuzkoa (DFG06/002, DFG08/001 and DFG15/221) and annual agreements with the municipalities of the study area (Zumarraga, Urretxu , Legazpi, Azkoitia y Azpeitia y Beasain).
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Collaborating Entities:
Buscador
Maternal body mass index, gestational weight gain, and the risk of overweight and obesity across childhood: An individual participant data meta-analysis
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Association of Gestational Weight Gain With Adverse Maternal and Infant Outcomes
LifeCycle Project-Maternal Obesity and Childhood Outcomes Study Group, Voerman E, Santos S, Inskip H, Amiano P, Barros H, Charles MA, Chatzi L, Chrousos GP, Corpeleijn E, Crozier S, Doyon M, Eggesbø M, Fantini MP, Farchi S, Forastiere F, Georgiu V, Gori D, Hanke W, Hertz-Picciotto I, Heude B, Hivert MF, Hryhorczuk D, Iñiguez C, Karvonen AM, Küpers LK, Lagström H, Lawlor DA, Lehmann I, Magnus P, Majewska R, Mäkelä J, Manios Y, Mommers M, Morgen CS, Moschonis G, Nohr EA, Nybo Andersen AM, Oken E, Pac A, Papadopoulou E, Pekkanen J, Pizzi C, Polanska K, Porta D, Richiardi L, Rifas-Shiman SL, Roeleveld N, Ronfani L, Santos AC, Standl M, Stigum H, Stoltenberg C, Thiering E, Thijs C, Torrent M, Trnovec T, van Gelder MMHJ, van Rossem L, von Berg A, Vrijheid M, Wijga A, Zvinchuk O, Sørensen TIA, Godfrey K, Jaddoe VWV, Gaillard R. Association of Gestational Weight Gain With Adverse Maternal and Infant Outcomes. JAMA. 2019 May 7;321(17):1702-1715. PMID: 31063572
Impact of maternal body mass index and gestational weight gain on pregnancy complications: an individual participant data meta-analysis of European, North American and Australian cohorts
Santos S, Voerman E, Amiano P, Barros H, Beilin LJ, Bergström A, Charles MA, Chatzi L, Chevrier C, Chrousos GP, Corpeleijn E, Costa O, Costet N, Crozier S, Devereux G, Doyon M, Eggesbø M, Fantini MP, Farchi S, Forastiere F, Georgiu V, Godfrey KM, Gori D, Grote V, Hanke W, Hertz-Picciotto I, Heude B, Hivert MF, Hryhorczuk D, Huang RC, Inskip H, Karvonen AM, Kenny LC, Koletzko B, Küpers LK, Lagström H, Lehmann I, Magnus P, Majewska R, Mäkelä J, Manios Y, McAuliffe FM, McDonald SW, Mehegan J, Melén E, Mommers M, Morgen CS, Moschonis G, Murray D, Ní Chaoimh C, Nohr EA, Nybo Andersen AM, Oken E, Oostvogels A, Pac A, Papadopoulou E, Pekkanen J, Pizzi C, Polanska K, Porta D, Richiardi L, Rifas-Shiman SL, Roeleveld N, Ronfani L, Santos AC, Standl M, Stigum H, Stoltenberg C, Thiering E, Thijs C, Torrent M, Tough SC, Trnovec T, Turner S, van Gelder M, van Rossem L, von Berg A, Vrijheid M, Vrijkotte T, West J, Wijga AH, Wright J, Zvinchuk O, Sørensen T, Lawlor DA, Gaillard R, Jaddoe V. Impact of maternal body mass index and gestational weight gain on pregnancy complications: an individual participant data meta-analysis of European, North American and Australian cohorts. BJOG. 2019 Jul;126(8):984-995. PMID: 30786138
Maternal nut intake in pregnancy and child neuropsychological development up to 8 years old: a population‑based cohort study in Spain
Gignac F, Romaguera D, Fernández-Barrés S, Phillipat C, Garcia Esteban R, López-Vicente M, Vioque J, Fernández-Somoano A, Tardón A, Iñiguez C, Lopez-Espinosa MJ, García de la Hera M, Amiano P, Ibarluzea J, Guxens M, Sunyer J, Julvez J. Maternal nut intake in pregnancy and child neuropsychological development up to 8 years old: a population‑based cohort study in Spain. Eur J Epidemiol. 2019 Jul;34(7):661-673. PMID: 31062119
Effect modification of FADS2 polymorphisms on the association between breastfeedingand intelligence: results from a collaborative meta-analysis
Hartwig FP, Davies NM, Horta BL, Ahluwalia TS, Bisgaard H, Bønnelykke K, Caspi A, Moffitt TE, Poulton R, Sajjad A, Tiemeier HW, Dalmau-Bueno A, Guxens M, Bustamante M, Santa-Marina L, Parker N, Paus T, Pausova Z, Lauritzen L, Schnurr TM, Michaelsen KF, Hansen T, Oddy W, Pennell CE, Warrington NM, Davey Smith G, Victora CG. Effect modification of FADS2 polymorphisms on the association between breastfeedingand intelligence: results from a collaborative meta-analysis. Int J Epidemiol. 2019 Feb 1;48(1):45-57. PMID: 30541029
Exposure and health risks perception of extremely low frequency and radiofrequency electromagnetic fields and the effect of providing information
Gallastegi M, Jiménez-Zabala A, Molinuevo A, Aurrekoetxea JJ, Santa-Marina L, Vozmediano L, Ibarluzea J. Exposure and health risks perception of extremely low frequency and radiofrequency electromagnetic fields and the effect of providing information. Environ Res. 2019 Feb;169:501-509. PMID: 30530090
Manganese levels in newborns’ hair by maternal sociodemographic, dietary and environmental factors
Irizar A, Gil F, Lertxundi A, Martín-Domingo MC, Urbieta N, Molinuevo A, Ibarluzea J, Basterrechea M, Aurrekoetxea JJ, Jiménez-Zabala A, Santa-Marina L. Manganese levels in newborns’ hair by maternal sociodemographic, dietary and environmental factors. Environ Res. 2019 Mar;170:92-100. PMID: 30576994
High doses of folic acid in the periconceptional period and risk of low weight for gestational age at birth in a population based cohor
Navarrete-Muñoz EM, Valera-Gran D, Garcia-de-la-Hera M, Gonzalez-Palacios S, Riaño I, Murcia M, Lertxundi A, Guxens M, Tardón A, Amiano P, Vrijheid M, Rebagliato M, Vioque J; INMA Project. High doses of folic acid in the periconceptional period and risk of low weight for gestational age at birth in a population based cohort study. Eur J Nutr. 2019 Feb;58(1):241-251. PMID: 29181588
Effect of employment and domestic load on fetal development and length of gestation in a birth cohort study
Arizo-Luque V, García AM, Estarlich M, Ballester F, Fernández-Tardón G, Tardón A, Guxens M, Vrijheid M, Lertxundi A, Santa-Marina L, Ronda-Pérez E. [Effect of employment and domestic load on fetal development and length of gestation in a birth cohort study]. Rev Esp Salud Publica. 2018 Aug 17;92. Spanish. PMID: 30106066
The Association of Mediterranean Diet during Pregnancy with Longitudinal Body Mass Index Trajectories and Cardiometabolic Risk in Early Childhood
Fernández-Barrés S, Vrijheid M, Manzano-Salgado CB, Valvi D, Martínez D, Iñiguez C, Jimenez-Zabala A, Riaño-Galán I, Navarrete-Muñoz EM, Santa-Marina L, Tardón A, Vioque J, Arija V, Sunyer J, Romaguera D; Infancia y Medio Ambiente (INMA) Project. The Association of Mediterranean Diet during Pregnancy with Longitudinal Body Mass Index Trajectories and Cardiometabolic Risk in Early Childhood. J Pediatr. 2019 Mar;206:119-127. PMID: 30429079
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