Gipuzkoa
In May 2006 the INMA project was set up in Gipuzkoa with the aim of evaluating the role of the environmental pollutants present in the air, water and diet in the growth and development of the children. The incorporation of the women to the cohort was made coinciding with the first echography of pregnancy control. Biological samples were taken (blood, urine, hair, placenta, etc.) and a series of questionnaires were complimented (general, diet, labour, environmental, etc.) to evaluate the impact of the environmental pollutants present in the air and the water of consumption, as well as an estimation of the polluting agents contributed by the diet.
The mothers were recruited from population visiting at the Hospital of Zumarraga, which includes the municipalities of the Goierri and the Alto and Medio Urola. They were selected of this area because of the characteristics of the services of the hospital and primary attention centre, as well as by the environmental characteristics: hard presence of metallurgical industry, high density of traffic, low levels of products derived from the disinfection in the consumption water and a rich diet in fish, together with certain degree of hypothyroidism in the pregnant women.
Since then, the pursuit of 640 women has been made in first and the third trimester of pregnancy. At the moment the pursuit is being made of 623 children in aspects of growth and neurobehavioural development.
-
Funders of INMA-Gipuzkoa cohort:
This study was funded by grants from Instituto de Salud Carlos III (FIS-PI06/0867, FIS-PI09/00090, FIS-PI13/02187 and FIS-PI18/01142 incl. FEDER funds), CIBERESP, Department of Health of the Basque Government (2005111093, 2009111069, 2013111089 and 2015111065), and the Provincial Government of Gipuzkoa (DFG06/002, DFG08/001 and DFG15/221) and annual agreements with the municipalities of the study area (Zumarraga, Urretxu , Legazpi, Azkoitia y Azpeitia y Beasain).
-
Collaborating Entities:
Buscador
First-trimester maternal concentrations of polyfluoroalkyl substances and fetal growth throughout pregnancy
Costa O, Iñiguez C, Manzano-Salgado CB, Amiano P, Murcia M, Casas M, Irizar A, Basterrechea M, Beneito A, Schettgen T, Sunyer J, Vrijheid M, Ballester F, Lopez-Espinosa MJ. First-trimester maternal concentrations of polyfluoroalkyl substances and fetal growth throughout pregnancy. Environ Int. 2019 Sep;130:104830. PMID: 31247476
Association between trans fatty acid intake and overweight including obesity in 4 to 5-year-old children from the INMA study
Scholz A, Navarrete-Muñoz EM, García-de-la-Hera M, Fernandez-Somoano A, Tardon A, Santa-Marina L, Pereda-Pereda E, Romaguera D, Guxens M, Beneito A, Iñiguez C, Vioque J. Association between trans fatty acid intake and overweight including obesity in 4 to 5-year-old children from the INMA study. Pediatr Obes. 2019 Sep;14(9):e12528. PMID: 30957427
Inorganic arsenic exposure and neuropsychological development of children of 4-5 years of age living in Spain
Signes-Pastor AJ, Vioque J, Navarrete-Muñoz EM, Carey M, García-Villarino M, Fernández-Somoano A, Tardón A, Santa-Marina L, Irizar A, Casas M, Guxens M, Llop S, Soler-Blasco R, García-de-la-Hera M, Karagas MR, Meharg AA. Inorganic arsenic exposure and neuropsychological development of children of 4-5 years of age living in Spain. Environ Res. 2019 Jul;174:135-142. PMID: 31075694
Associations of Maternal Cell-Phone Use During Pregnancy With Pregnancy Duration and Fetal Growth in 4 Birth Cohorts
Tsarna E, Reedijk M, Birks LE, Guxens M, Ballester F, Ha M, Jiménez-Zabala A, Kheifets L, Lertxundi A, Lim HR, Olsen J, González Safont L, Sudan M, Cardis E, Vrijheid M, Vrijkotte T, Huss A, Vermeulen R. Associations of Maternal Cell-Phone Use During Pregnancy With Pregnancy Duration and Fetal Growth in 4 Birth Cohorts. Am J Epidemiol. 2019 Jul 1;188(7):1270-1280. PMID: 30995291
Similarities and differences of dietary and other determinants of iodine status in pregnant women from three European birth cohorts
Dineva M, Rayman MP, Levie D, Guxens M, Peeters RP, Vioque J, González L, Espada M, Ibarluzea J, Sunyer J, Korevaar TIM, Bath SC. Similarities and differences of dietary and other determinants of iodine status in pregnant women from three European birth cohorts. Eur J Nutr. 2020 Feb;59(1):371-387. PMID: 30734058
The Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia: design, results and future prospects
Middeldorp CM, Felix JF, Mahajan A; EArly Genetics Lifecourse Epidemiology (EAGLE) consortium; Early Growth Genetics (EGG) consortium, McCarthy MI. The Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia: design, results and future prospects. Eur J Epidemiol. 2019 Mar;34(3):279-300. PMID: 30887376
Prenatal exposure to PM2.5 and NO2 and sex-dependent infant cognitive and motor development
Lertxundi A, Andiarena A, Martínez MD, Ayerdi M, Murcia M, Estarlich M, Guxens M, Sunyer J, Julvez J, Ibarluzea J. Prenatal exposure to PM2.5 and NO2 and sex-dependent infant cognitive and motor development. Environ Res. 2019 Jul;174:114-121. PMID: 31055169
Prenatal exposure to perfluoroalkyl substances, immune-related outcomes, and lung function in children from a Spanish birth cohort study
Manzano-Salgado CB, Granum B, Lopez-Espinosa MJ, Ballester F, Iñiguez C, Gascón M, Martínez D, Guxens M, Basterretxea M, Zabaleta C, Schettgen T, Sunyer J, Vrijheid M, Casas M. Prenatal exposure to perfluoroalkyl substances, immune-related outcomes, and lung function in children from a Spanish birth cohort study. Int J Hyg Environ Health. 2019 Jul;222(6):945-954. PMID: 31262703
Prenatal Omega-6:Omega-3 Ratio and Attention Deficit and Hyperactivity Disorder Symptoms
López-Vicente M, Ribas Fitó N, Vilor-Tejedor N, Garcia-Esteban R, Fernández-Barrés S, Dadvand P, Murcia M, Rebagliato M, Ibarluzea J, Lertxundi A, Fernández-Somoano A, Tardón A, López-Sabater MC, Romaguera D, Vrijheid M, Sunyer J, Julvez J. Prenatal Omega-6:Omega-3 Ratio and Attention Deficit and Hyperactivity Disorder Symptoms. J Pediatr. 2019 Jun;209:204-211. PMID: 30929929
Influence of the Urban Exposome on Birth Weight
Nieuwenhuijsen MJ, Agier L, Basagaña X, Urquiza J, Tamayo-Uria I, Giorgis-Allemand L, Robinson O, Siroux V, Maitre L, de Castro M, Valentin A, Donaire D, Dadvand P, Aasvang GM, Krog NH, Schwarze PE, Chatzi L, Grazuleviciene R, Andrusaityte S, Dedele A, McEachan R, Wright J, West J, Ibarluzea J, Ballester F, Vrijheid M, Slama R. Influence of the Urban Exposome on Birth Weight. Environ Health Perspect. 2019 Apr;127(4):47007. doi: 10.1289/EHP3971. PMID: 31009264
14 / 33
