Gipuzkoa
In May 2006 the INMA project was set up in Gipuzkoa with the aim of evaluating the role of the environmental pollutants present in the air, water and diet in the growth and development of the children. The incorporation of the women to the cohort was made coinciding with the first echography of pregnancy control. Biological samples were taken (blood, urine, hair, placenta, etc.) and a series of questionnaires were complimented (general, diet, labour, environmental, etc.) to evaluate the impact of the environmental pollutants present in the air and the water of consumption, as well as an estimation of the polluting agents contributed by the diet.
The mothers were recruited from population visiting at the Hospital of Zumarraga, which includes the municipalities of the Goierri and the Alto and Medio Urola. They were selected of this area because of the characteristics of the services of the hospital and primary attention centre, as well as by the environmental characteristics: hard presence of metallurgical industry, high density of traffic, low levels of products derived from the disinfection in the consumption water and a rich diet in fish, together with certain degree of hypothyroidism in the pregnant women.
Since then, the pursuit of 640 women has been made in first and the third trimester of pregnancy. At the moment the pursuit is being made of 623 children in aspects of growth and neurobehavioural development.
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Funders of INMA-Gipuzkoa cohort:
This study was funded by grants from Instituto de Salud Carlos III (FIS-PI06/0867, FIS-PI09/00090, FIS-PI13/02187 and FIS-PI18/01142 incl. FEDER funds), CIBERESP, Department of Health of the Basque Government (2005111093, 2009111069, 2013111089 and 2015111065), and the Provincial Government of Gipuzkoa (DFG06/002, DFG08/001 and DFG15/221) and annual agreements with the municipalities of the study area (Zumarraga, Urretxu , Legazpi, Azkoitia y Azpeitia y Beasain).
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Collaborating Entities:
Buscador
Risk and Protective Factors for Bullying at 11 Years of Age in a Spanish Birth Cohort Study
Babarro I, Andiarena A, Fano E, Lertxundi N, Vrijheid M, Julvez J, Barreto FB, Fossati S, Ibarluzea J. Risk and Protective Factors for Bullying at 11 Years of Age in a Spanish Birth Cohort Study. Int J Environ Res Public Health. 2020 Jun 19;17(12):4428. PMID: 32575610
Association of Lifestyle Factors and Neuropsychological Development of 4-Year-Old Children
O’Connor G, Julvez J, Fernandez-Barrés S, Navarrete-Muñoz EM, Murcia M, Tardón A, Galán IR, Amiano P, Ibarluzea J, Garcia-Esteban R, Vrijheid M, Sunyer J, Romaguera D. Association of Lifestyle Factors and Neuropsychological Development of 4-Year-Old Children. Int J Environ Res Public Health. 2020 Aug 5;17(16):E5668. PMID: 32764493
Early Life Exposure to Perfluoroalkyl Substances (PFAS) and ADHD: A Meta-Analysis of Nine European Population-Based Studies
Forns J, Verner MA, Iszatt N, Nowack N, Bach CC, Vrijheid M, Costa O, Andiarena A, Sovcikova E, Høyer BB, Wittsiepe J, Lopez-Espinosa MJ, Ibarluzea J, Hertz-Picciotto I, Toft G, Stigum H, Guxens M, Liew Z, Eggesbø M. Early Life Exposure to Perfluoroalkyl Substances (PFAS) and ADHD: A Meta-Analysis of Nine European Population-Based Studies. Environ Health Perspect. 2020 May;128(5):57002. PMID: 32378965
The LifeCycle Project-EU Child Cohort Network: a federated analysis infrastructure and harmonized data of more than 250,000 children and parents
Jaddoe VWV, Felix JF, Andersen AN, Charles MA, Chatzi L, Corpeleijn E, Donner N, Elhakeem A, Eriksson JG, Foong R, Grote V, Haakma S, Hanson M, Harris JR, Heude B, Huang RC, Inskip H, Järvelin MR, Koletzko B, Lawlor DA, Lindeboom M, McEachan RRC, Mikkola TM, Nader JLT, de Moira AP, Pizzi C, Richiardi L, Sebert S, Schwalber A, Sunyer J, Swertz MA, Vafeiadi M, Vrijheid M, Wright J, Duijts L; LifeCycle Project Group. The LifeCycle Project-EU Child Cohort Network: a federated analysis infrastructure and harmonized data of more than 250,000 children and parents. Eur J Epidemiol. 2020 Jul;35(7):709-724. PMID: 32705500
Associations between air pollution and pediatric eczema, rhinoconjunctivitis and asthma: A meta-analysis of European birth cohorts
Fuertes E, Sunyer J, Gehring U, Porta D, Forastiere F, Cesaroni G, Vrijheid M, Guxens M, Annesi-Maesano I, Slama R, Maier D, Kogevinas M, Bousquet J, Chatzi L, Lertxundi A, Basterrechea M, Esplugues A, Ferrero A, Wright J, Mason D, McEachan R, Garcia-Aymerich J, Jacquemin B. Associations between air pollution and pediatric eczema, rhinoconjunctivitis and asthma: A meta-analysis of European birth cohorts. Environ Int. 2020 Mar;136:105474. PMID: 31962272
Association of placental concentrations of phenolic endocrine disrupting chemicals with cognitive functioning in preschool children from the Environment and Childhood (INMA) Project
Freire C, Vela-Soria F, Beneito A, Lopez-Espinosa MJ, Ibarluzea J, Barreto FB, Casas M, Vrijheid M, Fernandez-Tardon G, Riaño-Galan I, Fernandez MF; INMA Project. Association of placental concentrations of phenolic endocrine disrupting chemicals with cognitive functioning in preschool children from the Environment and Childhood (INMA) Project. Int J Hyg Environ Health. 2020 Aug 11;230:113597. PMID: 32795877
Prenatal air pollution exposure and growth and cardio-metabolic risk in preschoolers
Fossati S, Valvi D, Martínez D, Cirach M, Estarlich M, Fernández-Somoano A, Guxens M, Iñiguez C, Irizar A, Lertxundi A, Nieuwenhuijsen M, Tamayo I, Vioque J, Tardón A, Sunyer J, Vrijheid M. Prenatal air pollution exposure and growth and cardio-metabolic risk in preschoolers. Environ Int. 2020 May;138:105619. PMID: 32193046
Maternal Thyroid Function in Early Pregnancy and Child Attention-Deficit Hyperactivity Disorder: An Individual-Participant Meta-Analysis
Levie D, Korevaar TIM, Mulder TA, Bath SC, Dineva M, Lopez-Espinosa MJ, Basterrechea M, Santa-Marina L, Rebagliato M, Sunyer J, Rayman MP, Tiemeier H, Peeters RP, Guxens M. Maternal Thyroid Function in Early Pregnancy and Child Attention-Deficit Hyperactivity Disorder: An Individual-Participant Meta-Analysis. Thyroid. 2019 Sep;29(9):1316-1326. PMID: 31426724
Association of Exposure to Ambient Air Pollution With Thyroid Function During Pregnancy
Ghassabian A, Pierotti L, Basterrechea M, Chatzi L, Estarlich M, Fernández-Somoano A, Fleisch AF, Gold DR, Julvez J, Karakosta P, Lertxundi A, Lopez-Espinosa MJ, Mulder TA, Korevaar TIM, Oken E, Peeters RP, Rifas-Shiman S, Stephanou E, Tardón A, Tiemeier H, Vrijheid M, Vrijkotte TGM, Sunyer J, Guxens M. Association of Exposure to Ambient Air Pollution With Thyroid Function During Pregnancy. JAMA Netw Open. 2019 Oct 2;2(10):e1912902. PMID: 31617922
Association of Thyroid Function Test Abnormalities and Thyroid Autoimmunity With Preterm Birth: A Systematic Review and Meta-analysis
Consortium on Thyroid and Pregnancy—Study Group on Preterm Birth, Korevaar TIM, Derakhshan A, Taylor PN, Meima M, Chen L, Bliddal S, Carty DM, Meems M, Vaidya B, Shields B, Ghafoor F, Popova PV, Mosso L, Oken E, Suvanto E, Hisada A, Yoshinaga J, Brown SJ, Bassols J, Auvinen J, Bramer WM, López-Bermejo A, Dayan C, Boucai L, Vafeiadi M, Grineva EN, Tkachuck AS, Pop VJM, Vrijkotte TG, Guxens M, Chatzi L, Sunyer J, Jiménez-Zabala A, Riaño I, Murcia M, Lu X, Mukhtar S, Delles C, Feldt-Rasmussen U, Nelson SM, Alexander EK, Chaker L, Männistö T, Walsh JP, Pearce EN, Steegers EAP, Peeters RP. Association of Thyroid Function Test Abnormalities and Thyroid Autoimmunity With Preterm Birth: A Systematic Review and Meta-analysis. JAMA. 2019 Aug 20;322(7):632-641. PMID: 31429897
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