Gipuzkoa
In May 2006 the INMA project was set up in Gipuzkoa with the aim of evaluating the role of the environmental pollutants present in the air, water and diet in the growth and development of the children. The incorporation of the women to the cohort was made coinciding with the first echography of pregnancy control. Biological samples were taken (blood, urine, hair, placenta, etc.) and a series of questionnaires were complimented (general, diet, labour, environmental, etc.) to evaluate the impact of the environmental pollutants present in the air and the water of consumption, as well as an estimation of the polluting agents contributed by the diet.
The mothers were recruited from population visiting at the Hospital of Zumarraga, which includes the municipalities of the Goierri and the Alto and Medio Urola. They were selected of this area because of the characteristics of the services of the hospital and primary attention centre, as well as by the environmental characteristics: hard presence of metallurgical industry, high density of traffic, low levels of products derived from the disinfection in the consumption water and a rich diet in fish, together with certain degree of hypothyroidism in the pregnant women.
Since then, the pursuit of 640 women has been made in first and the third trimester of pregnancy. At the moment the pursuit is being made of 623 children in aspects of growth and neurobehavioural development.
-
Funders of INMA-Gipuzkoa cohort:
This study was funded by grants from Instituto de Salud Carlos III (FIS-PI06/0867, FIS-PI09/00090, FIS-PI13/02187 and FIS-PI18/01142 incl. FEDER funds), CIBERESP, Department of Health of the Basque Government (2005111093, 2009111069, 2013111089 and 2015111065), and the Provincial Government of Gipuzkoa (DFG06/002, DFG08/001 and DFG15/221) and annual agreements with the municipalities of the study area (Zumarraga, Urretxu , Legazpi, Azkoitia y Azpeitia y Beasain).
-
Collaborating Entities:
Buscador
Association of maternal thyroid function with birthweight: a systematic review and individual-participant data meta-analysis
Derakhshan A, Peeters RP, Taylor PN, Bliddal S, Carty DM, Meems M, Vaidya B, Chen L, Knight BA, Ghafoor F, Popova PV, Mosso L, Oken E, Suvanto E, Hisada A, Yoshinaga J, Brown SJ, Bassols J, Auvinen J, Bramer WM, López-Bermejo A, Dayan CM, French R, Boucai L, Vafeiadi M, Grineva EN, Pop VJM, Vrijkotte TG, Chatzi L, Sunyer J, Jiménez-Zabala A, Riaño I, Rebagliato M, Lu X, Pirzada A, Männistö T, Delles C, Feldt-Rasmussen U, Alexander EK, Nelson SM, Chaker L, Pearce EN, Guxens M, Steegers EAP, Walsh JP, Korevaar TIM. Association of maternal thyroid function with birthweight: a systematic review and individual-participant data meta-analysis. Lancet Diabetes Endocrinol. 2020 Jun;8(6):501-510. PMID: 32445737
Maternal Iodine Status During Pregnancy Is Not Consistently Associated with Attention-Deficit Hyperactivity Disorder or Autistic Traits in Children
Levie D, Bath SC, Guxens M, Korevaar TIM, Dineva M, Fano E, Ibarluzea JM, Llop S, Murcia M, Rayman MP, Sunyer J, Peeters RP, Tiemeier H. Maternal Iodine Status During Pregnancy Is Not Consistently Associated with Attention-Deficit Hyperactivity Disorder or Autistic Traits in Children. J Nutr. 2020 Jun 1;150(6):1516-1528. PMID: 32171006
Residential Surrounding Greenspace and Mental Health in Three Spanish Areas
Torres Toda M, Anabitarte Riol A, Cirach M, Estarlich M, Fernández-Somoano A, González-Safont L, Guxens M, Julvez J, Riaño-Galán I, Sunyer J, Dadvand P. Residential Surrounding Greenspace and Mental Health in Three Spanish Areas. Int J Environ Res Public Health. 2020 Aug 5;17(16):E5670. PMID: 32764502
Prenatal manganese exposure and neuropsychological development in early childhood in the INMA cohort
Soler-Blasco R, Murcia M, Lozano M, González-Safont L, Amorós R, Ibarluzea J, Broberg K, Irizar A, Lopez-Espinosa MJ, Lertxundi N, Marina LS, Ballester F, Llop S. Prenatal manganese exposure and neuropsychological development in early childhood in the INMA cohort. Int J Hyg Environ Health. 2020 Mar;224:113443. PMID: 31978738
Postnatal exposure to mercury and neuropsychological development among preschooler children
Llop S, Murcia M, Amorós R, Julvez J, Santa-Marina L, Soler-Blasco R, Rebagliato M, Iñiguez C, Aguinagalde X, Iriarte G, Lopez-Espinosa MJ, Andiarena A, Gonzalez L, Vioque J, Sunyer J, Ballester F. Postnatal exposure to mercury and neuropsychological development among preschooler children. Eur J Epidemiol. 2020 Mar;35(3):259-271. PMID: 32170664
Early childhood growth is associated with lung function at 7 years: a prospective population-based study
Peralta GP, Abellan A, Montazeri P, Basterrechea M, Esplugues A, González-Palacios S, Roda C, Santa-Marina L, Sunyer J, Vrijheid M, Casas M, Garcia-Aymerich J. Early childhood growth is associated with lung function at 7 years: a prospective population-based study. Eur Respir J. 2020 Dec 24;56(6):2000157. PMID: 32855223
Applying the exposome concept in birth cohort research: a review of statistical approaches
Santos S, Maitre L, Warembourg C, Agier L, Richiardi L, Basagaña X, Vrijheid M. Applying the exposome concept in birth cohort research: a review of statistical approaches. Eur J Epidemiol. 2020 Mar;35(3):193-204. PMID: 32221742
Risk of child poverty and social exclusion in two Spanish regions: social and family determinants
González L, Estarlich M, Murcia M, Larrañaga I, Barreto FB, Santa-Marina L, Arranz E, Cirugeda L, Simó S, Rebagliato M. Risk of child poverty and social exclusion in two Spanish regions: social and family determinants. Gac Sanit. May-Jun 2021;35(3):216-223. PMID: 31980149
Prenatal Manganese Exposure and Long-Term Neuropsychological Development at 4 Years of Age in a Population-Based Birth Cohort
Andiarena A, Irizar A, Molinuevo A, Urbieta N, Babarro I, Subiza-Pérez M, Santa-Marina L, Ibarluzea J, Lertxundi A. Prenatal Manganese Exposure and Long-Term Neuropsychological Development at 4 Years of Age in a Population-Based Birth Cohort. Int J Environ Res Public Health. 2020 Mar 4;17(5):1665.PMID: 32143391
Integrative Strategy of Testing Systems for Identification of Endocrine Disruptors Inducing Metabolic Disorders-An Introduction to the OBERON Project
Audouze K, Sarigiannis D, Alonso-Magdalena P, Brochot C, Casas M, Vrijheid M, Babin PJ, Karakitsios S, Coumoul X, Barouki R. Integrative Strategy of Testing Systems for Identification of Endocrine Disruptors Inducing Metabolic Disorders-An Introduction to the OBERON Project. Int J Mol Sci. 2020 Apr 23;21(8):2988. PMID: 32340264
11 / 33