Gipuzkoa
In May 2006 the INMA project was set up in Gipuzkoa with the aim of evaluating the role of the environmental pollutants present in the air, water and diet in the growth and development of the children. The incorporation of the women to the cohort was made coinciding with the first echography of pregnancy control. Biological samples were taken (blood, urine, hair, placenta, etc.) and a series of questionnaires were complimented (general, diet, labour, environmental, etc.) to evaluate the impact of the environmental pollutants present in the air and the water of consumption, as well as an estimation of the polluting agents contributed by the diet.
The mothers were recruited from population visiting at the Hospital of Zumarraga, which includes the municipalities of the Goierri and the Alto and Medio Urola. They were selected of this area because of the characteristics of the services of the hospital and primary attention centre, as well as by the environmental characteristics: hard presence of metallurgical industry, high density of traffic, low levels of products derived from the disinfection in the consumption water and a rich diet in fish, together with certain degree of hypothyroidism in the pregnant women.
Since then, the pursuit of 640 women has been made in first and the third trimester of pregnancy. At the moment the pursuit is being made of 623 children in aspects of growth and neurobehavioural development.
-
Funders of INMA-Gipuzkoa cohort:
This study was funded by grants from Instituto de Salud Carlos III (FIS-PI06/0867, FIS-PI09/00090, FIS-PI13/02187 and FIS-PI18/01142 incl. FEDER funds), CIBERESP, Department of Health of the Basque Government (2005111093, 2009111069, 2013111089 and 2015111065), and the Provincial Government of Gipuzkoa (DFG06/002, DFG08/001 and DFG15/221) and annual agreements with the municipalities of the study area (Zumarraga, Urretxu, Ordizia, Legazpi, Azkoitia y Azpeitia y Beasain).
-
Collaborating Entities:
Buscador
Prenatal Metals Exposure and pre-adolescents’ Emotional and Behavioral Problems
Manuel Lozano, Karin Broberg, Raquel Soler-Blasco, Gabriel Riutort-Mayol, Ferran Ballester, Llúcia González, Mario Murcia, Joan O. Grimalt, Fernando Gil, Pablo Olmedo, Simone Braeuer, Maribel Casas, Mònica Guxens, Amaia Irizar, Nerea Lertxundi, Miren Begoña Zubero, Loreto Santa Marina & Sabrina Llop. Prenatal Metals Exposure and pre-adolescents’ Emotional and Behavioral Problems. Expo Health 16, 679–692 (2024). https://link.springer.com/article/10.1007/s12403-023-00585-6
Prenatal arsenic speciation and thyroid hormone levels during pregnancy and adolescence
Llop S, Lönnqvist J, Lopez-Espinosa MJ, Murcia M, Santa-Marina L, Ballester F, Irizar A, Braeuer S, Esplugues A, Lozano M, Vallejo-Ortega J, García-Baquero G, Barroeta Z, Harari F, Soler-Blasco R. Prenatal arsenic speciation and thyroid hormone levels during pregnancy and adolescence. Environ Res. 2026 Mar 15;293:123773. PMID: 41539525
Saliva as a potential diagnostic medium: DNA methylation biomarkers for disorders beyond the oral cavity
Hernangomez-Laderas A, Cilleros-Portet A, Marí S, González-García BP, Arregi A, Jimeno-Romero A, Irizar A, García-Santisteban I, Lesseur C, Fernandez-Jimenez N, Bilbao JR. Saliva as a potential diagnostic medium: DNA methylation biomarkers for disorders beyond the oral cavity. NPJ Genom Med. 2025 Jun 20;10(1):49. PMID: 40541940
Tracking early-life PFAS exposure in children at ages 4, 8, and 14 years: A longitudinal study from the INMA Spanish birth cohort
San Román A, Abilleira E, González-Gaya B, Ayala-Cabrera JF, Barroeta Z, Etxebarria N, Irizar A. Tracking early-life PFAS exposure in children at ages 4, 8, and 14 years: A longitudinal study from the INMA Spanish birth cohort. Environ Res. 2025 Oct 15;283:122198. PMID: 40543869.
Gene-Environment Interaction Affects Risk of Atopic Eczema: Population and In Vitro Studies
Standl M, Budu-Aggrey A, Johnston LJ, Elias MS, Arshad SH, Bager P, Bataille V, Blakeway H, Bønnelykke K, Boomsma D, Brumpton BM, Bustamante Pineda M, Campbell A, Curtin JA, Eliasen A, Fadista JPS, Feenstra B, Gerner T, Medina-Gomez C, Grosche S, Gutzkow KB, Halling AS, Hayward C, Henderson J, Herrera-Luis E, Holloway JW, Hottenga J, O’B Hourihane J, Hu C, Hveem K, Irizar A, Jacquemin B, Jessen L, Kress S, Kurukulaaratchy RJ, Lau S, Llop S, Løset M, Marenholz I, Mason D, McCartney DL, Melbye M, Melén E, Minica C, Murray CS, Nijsten T, Pardo LM, Pasmans S, Pennell CE, Rinnov MR, Santorelli G, Schikowski T, Sheehan D, Simpson A, Söderhäll C, Thomas LF, Thyssen JP, Torrent M, van Beijsterveldt T, Visconti A, Vonk JM, Wang CA, Xu CJ, Ziyab AH; UK Translational Research Network in Dermatology; BIOMAP Consortium; Custovic A, Di Meglio P, Duijts L, Flohr C, Irvine AD, Koppelman GH, Lee YA, Reynolds NJ, Smith C, Langan SM, Paternoster L, Brown SJ. Gene-Environment Interaction Affects Risk of Atopic Eczema: Population and In Vitro Studies. Allergy. 2025 Aug;80(8):2201-2212. PMID: 40462597. Erratum in: Allergy. 2026 Feb;81(2):626. PMID: 40958161 .
Association of gestational thyroid function and thyroid autoimmunity with gestational diabetes: a systematic review and individual participant meta-analysis
Osinga JAJ, Derakhshan A, Karachaliou M, Poppe KG, Warringa L, Verdonk K, Vaidya B, Männistö T, López-Bermejo A, Bassols J, Broeren MAC, Brown SJ, Jensen RC, Popova PV, Pop VJM, Feldt-Rasmussen U, Aminorroaya A, Bliddal S, Mosso L, Chatzi L, Boucai L, Itoh S, Kishi R, Kleynen P, Ashoor G, Oken E, Grineva EN, Lu X, Lertxundi A, Murcia M, Meertens-Gunput STG, Rebagliato M, Riaño-Galán I, Irizar A, Vrijheid M, Fernández-Somoano A, Suvanto E, Guxens M, Daraki V, Mathieu C, Kianpour M, Glintborg D, Jensen TK, Alexander E, Chaker L, Malone F, Messerlian G, Hattersley A, Harley KG, Pearce EN, Visser WE, Vrijkotte TGM, Peeters RP, Palomaki GE, Lowe W, Eskenazi B, Chen LM, Walsh JP, Nicolaides KH, Carty DM, Delles C, Tao FB, Huang K, Maraka S, D’Alton ME, Painter RC, Andersen MS, Benhalima K, Korevaar TIM. Association of gestational thyroid function and thyroid autoimmunity with gestational diabetes: a systematic review and individual participant meta-analysis. Lancet Diabetes Endocrinol. 2025 Aug;13(8):651-661. PMID: 40609565
Understanding Social Inequalities in Childhood Asthma: Quantifying the Mediating Role of Modifiable Early-Life Risk Factors in Seven European Birth Cohorts
Pinot de Moira A, Aurup AV, Avraam D, Zugna D, Jensen AKG, Welten M, Cadman T, de Lauzon-Guillain B, Duijts L, Elhakeem A, Esplugues A, Garcia-Aymerich J, García-Baquero G, González Safont L, Harris JR, Iñiguez C, Jaddoe VWV, McEachan RRC, Nader JLT, Santa Marina L, Swertz MA, Tafflet M, Vrijheid M, Wright J, Yang TC, Taylor-Robinson D, Richiardi L, Nybo Andersen AM. Understanding Social Inequalities in Childhood Asthma: Quantifying the Mediating Role of Modifiable Early-Life Risk Factors in Seven European Birth Cohorts. J Allergy Clin Immunol Pract. 2025 Jun;13(6):1385-1396. PMID: 40314625
Association of environmental noise exposure with cortisol levels in children from eight European birth cohorts
Arregi A, Robinson O, Aasvang GM, Andrusaityte S, Dedele A, Evandt J, Garcia-Baquero G, Krog NH, Guxens M, Jaddoe VWV, Karachaliou M, Lertxundi A, Margetaki K, McEachan R, Nieuwenhuijsen M, Philippat C, Pozo OJ, Slama R, Subiza-Pérez M, van Rossum EFC, Vrijheid M, Wright J, Yang TC, Vegas O, Lertxundi N. Association of environmental noise exposure with cortisol levels in children from eight European birth cohorts. Environ Res. 2025 Jul 15;277:121541. PMID: 40203977
Particulate matter exposure during pregnancy and birth outcomes: exposure windows of susceptibility and socioeconomic inequalities
Guxens M, Botella N, Stafoggia M, Canto M, Petricola S, Valentín A, Lertxundi A, Fernández-Somoano A, Freire C, García-Altés A, Diez E, Marí-Dell’Olmo M, Iñiguez C, López MJ, Ramis R, Binter AC. Particulate matter exposure during pregnancy and birth outcomes: exposure windows of susceptibility and socioeconomic inequalities. Eur J Epidemiol. 2025 Sep;40(9):1105-1121. PMID: 40705228
Early-life growth and emotional, behavior and cognitive outcomes in childhood and adolescence in the EU child cohort network: individual participant data meta-analysis of over 109,000 individuals
Gonçalves R, Blaauwendraad S, Avraam D, Beneíto A, Charles MA, Elhakeem A, Escribano J, Etienne L, García-Baquero Moneo G, Soares AG, de Groot J, Grote V, Gruszfeld D, Guerlich K, Guxens M, Heude B, Koletzko B, Lertxundi A, Lozano M, El Marroun H, McEachan R, Pinot de Moira A, Santorelli G, Strandberg-Larsen K, Tafflet M, Vainqueur C, Verduci E, Vrijheid M, Welten M, Wright J, Yang TC, Gaillard R, Jaddoe VWV. Early-life growth and emotional, behavior and cognitive outcomes in childhood and adolescence in the EU child cohort network: individual participant data meta-analysis of over 109,000 individuals. Lancet Reg Health Eur. 2025 Feb 26;52:101247. PMID: 40094119
1 / 38
