Asturias

The Unit of Molecular Epidemiology of the University Institute of Oncology of the University of Oviedo initiated in 2004 in Asturias one cohort of new born children, at the 12th week of pregnancy, of the population of Sanitary Area III. The objective was to study the paper of the environmental exposures in the children’s development (neurobehavioural and anthropometric) and health (mainly respiratory), in the frame of the INMA (Childhood and Environment) network, a project financed by the Institute of Health Carlos III. It is an observational study of cohorts that follows pregnant women of the general population from the first trimester to the childbirth and their children from the birth to the adolescence. The women had to be resident in Area III of Asturias, with age equal or over 16 years, and they were recruited between 2004 and 2006. Other criteria of inclusion were: unique pregnancy, no problems for a fluent communication, and not to suffer any chronic disease.

The Sanitary area III of Asturias includes the councils of Avilés, Corvera, Castrillón, Gozón, Cudillero, Pravia, Paredes de Nalón, and Soto del Barco, with their primary attention centre in the Hospital San Agustín de Avilés. The area is particular because of a high level of industrialisation that has offered a good opportunity to create one cohort from the pregnancy: the size of population allowed to recruit in 2 years the number of required pregnant women; the integration of its sanitary structure enabled that all the pregnant women attended the same centre of secondary attention for the first visit and echography a and an only hospital for the childbirth.

The recruited cohort presents characteristics common of the pregnancies in our surroundings (average age 31.82 years, occupation during the pregnancy 70.51%, smoking in the third trimester of pregnancy 17.76%), although the participants had a certain selection towards one better education and social support that the average: education superior to the primary one 81.85%, biparental family at the birth of the child 99.38%. Nevertheless the variability in the exposures, both contamination and diet, assures that it is a contextual frame of great value for the proposed study.

Collected data includes individual exposure to atmospheric contamination during pregnancy, intrauterine and post-birth growth, mental development to the year and a half, and diet and nutrients during the pregnancy and to the year and a half of age. Blood of the mother, cord blood and maternal milk were also taken. The pursuit to the 18 months of age is being completed, with an answer of 92%.

 

  • Entidades Colaboradoras:

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176 Results

Physical activity - sedentary lifestyle -
Respiratory health and atopy -


Physical activity, sedentary behaviour, and childhood asthma: a European collaborative analysis

Eijkemans M, Mommers M, Harskamp-van Ginkel MW, Vrijkotte TGM, Ludvigsson J, Faresjö Å, Bergström A, Ekström S, Grote V, Koletzko B, Bønnelykke K, Eliasen AU, Bager P, Melbye M, Annesi-Maesano I, Baïz N, Barros H, Santos AC, Duijts L, Mensink-Bout SM, Flexeder C, Koletzko S, Schikowski T, Eggesbø MÅ, Lenters V, Fernández-Tardón G, Subiza-Perez M, Garcia-Aymerich J, López-Vicente M, Sunyer J, Torrent M, Ballester F, Kelleher C, Mehegan J, Berg AV, Herberth G, Standl M, Kuehni CE, Pedersen ESL, Jansen M, Gehring U, Boer JMA, Devereux G, Turner S, Peltola V, Lagström H, Inskip HM, Pike KC, Dalmeijer GW, Ent CKV, Thijs C. Physical activity, sedentary behaviour, and childhood asthma: a European collaborative analysis. BMJ Open Respir Res. 2024 Aug 15;11(1):e001630. PMID: 39147399


Air pollution -
Air pollution -
Vitamin D -
Vitamin D -


Associations of gestational exposure to air pollution with maternal vitamin D levels: a meta-analysis

Binter AC, Ghassabian A, Zou R, El Marroun H, Lertxundi A, Switkowski KM, Estarlich M, Rodríguez-Dehli AC, Esplugues A, Vrijkotte T, Sunyer J, Santa-Marina L, Fernández-Somoano A, Polanska K, McEachan RRC, Oken E, Tiemeier H, Guxens M. Associations of gestational exposure to air pollution with maternal vitamin D levels: a meta-analysis. J Clin Endocrinol Metab. 2024 Jun 13:dgae395. doi: 10.1210/clinem/dgae395. Epub ahead of print. PMID: 38870315


Intrauterine growth -
Intrauterine growth -
Meteorology -
Meteorology -
Reproductive health -
Reproductive health -


Ambient air temperature exposure and foetal size and growth in three European birth cohorts

Essers E, Granés L, Delaney S, Ballester J, Santos S, Petricola S, Yang TC, Fernández-Somoano A, Bereziartua A, Ballester F, Tardón A, Vrijheid M, Lertxundi A, McEachan RRC, El Marroun H, Tiemeier H, Iñiguez C, Guxens M. Ambient air temperature exposure and foetal size and growth in three European birth cohorts. Environ Int. 2024 Apr;186:108619. PMID: 38603813


Metals -
Metals -
Neurodevelopment -
Neurodevelopment -
Nutrition -
Nutrition -


The impact of prenatal mercury on neurobehavioral functioning longitudinally assessed from a young age to pre-adolescence in a Spanish birth cohort

Sarzo B, Ballester F, Soler-Blasco R, Sunyer J, Lopez-Espinosa MJ, Ibarluzea J, Lozano M, Julvez J, Iriarte G, Subiza-Perez M, González-Safont L, Fernández-Somoano A, Vallejo-Ortega J, Guxens M, López-González UA, Riaño-Galán I, Riutort-Mayol G, Murcia M, Llop S. The impact of prenatal mercury on neurobehavioral functioning longitudinally assessed from a young age to pre-adolescence in a Spanish birth cohort. Environ Res. 2024 Jul 1;252(Pt 2):118954. PMID: 38631469


Neurodevelopment -
Neurodevelopment -


Association between telomere length and neuropsychological function at 4-5 years in children from the INMA project: a cross-sectional study

Campos-Sánchez I, Navarrete-Muñoz EM, Hurtado-Pomares M, Júlvez J, Lertxundi N, Martens DS, Fernández-Somoano A, Riaño-Galán I, Guxens M, Ibarluzea JM, Nawrot T, Valera-Gran D. Association between telomere length and neuropsychological function at 4-5 years in children from the INMA project: a cross-sectional study. Eur Child Adolesc Psychiatry. 2024 Aug;33(8):2803-2812. PMID: 38246982


Breastfeeding -
Breastfeeding -
Reproductive health -
Reproductive health -


Mediators of the association between maternal body mass index and breastfeeding duration in 3 international cohorts

Keyes M, Andrews C, Midya V, Carrasco P, Guxens M, Jimeno-Romero A, Murcia M, Rodriguez-Dehli C, Romaguera D, Santa-Maria L, Vafeiadi M, Chatzi L, Oken E, Vrijheid M, Valvi D, Sen S. Mediators of the association between maternal body mass index and breastfeeding duration in 3 international cohorts. Am J Clin Nutr. 2023 Jul;118(1):255-263. PMID: 37407164


Neurodevelopment -
Neurodevelopment -
Reproductive health -
Reproductive health -


Association between relative age at school and persistence of ADHD in prospective studies: an individual participant data meta-analysis

Synergy for the Influence of the Month of Birth in ADHD (SIMBA) study group. Association between relative age at school and persistence of ADHD in prospective studies: an individual participant data meta-analysis. Lancet Psychiatry. 2023 Dec;10(12):922-933. PMID: 37898142


Air pollution -
Air pollution -
Intrauterine growth -
Intrauterine growth -


Susceptible windows of exposure to fine particulate matter and fetal growth trajectories in the Spanish INMA (INfancia y Medio Ambiente) birth cohort

Chen WJ, Rector AM, Guxens M, Iniguez C, Swartz MD, Symanski E, Ibarluzea J, Ambros A, Estarlich M, Lertxundi A, Riano-Galán I, Sunyer J, Fernandez-Somoano A, Chauhan SP, Ish J, Whitworth KW. Susceptible windows of exposure to fine particulate matter and fetal growth trajectories in the Spanish INMA (INfancia y Medio Ambiente) birth cohort. Environ Res. 2023 Jan 1;216(Pt 2):114628. PMID: 36279916


Physical activity - sedentary lifestyle -
Air pollution -
Built environment and Greeness -
Air pollution -
Postnatal growth and Obesity -
Social inequalities -
Entorno urbano y Verdor -
Neurodevelopment -
Neurodevelopment -
Physical activity - sedentary lifestyle -
Postnatal growth and Obesity -
Social inequalities -


Social inequalities, green and blue spaces and mental health in 6-12 years old children participating in the INMA cohort

Subiza-Pérez M, García-Baquero G, Fernández-Somoano A, Riaño I, González L, Delgado-Saborit JM, Guxens M, Fossati S, Vrijheid M, Fernandes A, Ibarluzea J, Lertxundi N. Social inequalities, green and blue spaces and mental health in 6-12 years old children participating in the INMA cohort. Health Place. 2023 Sep;83:103104. PMID: 37611380


Physical activity - sedentary lifestyle -
Air pollution -
Built environment and Greeness -
Air pollution -
Postnatal growth and Obesity -
Social inequalities -
Entorno urbano y Verdor -
Neurodevelopment -
Neurodevelopment -
Physical activity - sedentary lifestyle -
Postnatal growth and Obesity -
Social inequalities -


Residential green and blue spaces and working memory in children aged 6-12 years old. Results from the INMA cohort

Subiza-Pérez M, García-Baquero G, Fernández-Somoano A, Guxens M, González L, Tardón A, Dadvand P, Estarlich M, de Castro M, McEachan RRC, Ibarluzea J, Lertxundi N. Residential green and blue spaces and working memory in children aged 6-12 years old. Results from the INMA cohort. Health Place. 2023 Nov;84:103136. PMID: 37871446


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