Asturias
The Unit of Molecular Epidemiology of the University Institute of Oncology of the University of Oviedo initiated in 2004 in Asturias one cohort of new born children, at the 12th week of pregnancy, of the population of Sanitary Area III. The objective was to study the paper of the environmental exposures in the children’s development (neurobehavioural and anthropometric) and health (mainly respiratory), in the frame of the INMA (Childhood and Environment) network, a project financed by the Institute of Health Carlos III. It is an observational study of cohorts that follows pregnant women of the general population from the first trimester to the childbirth and their children from the birth to the adolescence. The women had to be resident in Area III of Asturias, with age equal or over 16 years, and they were recruited between 2004 and 2006. Other criteria of inclusion were: unique pregnancy, no problems for a fluent communication, and not to suffer any chronic disease.
The Sanitary area III of Asturias includes the councils of Avilés, Corvera, Castrillón, Gozón, Cudillero, Pravia, Paredes de Nalón, and Soto del Barco, with their primary attention centre in the Hospital San Agustín de Avilés. The area is particular because of a high level of industrialisation that has offered a good opportunity to create one cohort from the pregnancy: the size of population allowed to recruit in 2 years the number of required pregnant women; the integration of its sanitary structure enabled that all the pregnant women attended the same centre of secondary attention for the first visit and echography a and an only hospital for the childbirth.
The recruited cohort presents characteristics common of the pregnancies in our surroundings (average age 31.82 years, occupation during the pregnancy 70.51%, smoking in the third trimester of pregnancy 17.76%), although the participants had a certain selection towards one better education and social support that the average: education superior to the primary one 81.85%, biparental family at the birth of the child 99.38%. Nevertheless the variability in the exposures, both contamination and diet, assures that it is a contextual frame of great value for the proposed study.
Collected data includes individual exposure to atmospheric contamination during pregnancy, intrauterine and post-birth growth, mental development to the year and a half, and diet and nutrients during the pregnancy and to the year and a half of age. Blood of the mother, cord blood and maternal milk were also taken. The pursuit to the 18 months of age is being completed, with an answer of 92%.
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Entidades Colaboradoras:
Buscador
Tracking between cardiovascular-related measures at 4 and 8 years of age in the INMA-Asturias cohort
Fernández-Iglesias R, Martinez-Camblor P, Fernández-Somoano A, Rodríguez-Dehli C, Venta-Obaya R, Karagas MR, Tardón A, Riaño-Galán I. Tracking between cardiovascular-related measures at 4 and 8 years of age in the INMA-Asturias cohort. Eur J Pediatr. 2023 Sep;182(9):3893-3906. PMID: 37338691
Folic Acid Supplementation during Pregnancy and Its Association with Telomere Length in Children at Four Years: Results from the INMA Birth Cohort Study
Petermann-Rocha F, Valera-Gran D, Prieto-Botella D, Martens DS, Gonzalez-Palacios S, Riaño-Galán I, Murcia M, Irizar A, Julvez J, Santa-Marina L, Tardón A, Sunyer J, Vioque J, Nawrot T, Navarrete-Muñoz EM. Folic Acid Supplementation during Pregnancy and Its Association with Telomere Length in Children at Four Years: Results from the INMA Birth Cohort Study. Nutrients. 2023 Oct 9;15(19):4303. PMID: 37836587
Sedentary Behaviour and Telomere Length Shortening during Early Childhood: Evidence from the Multicentre Prospective INMA Cohort Study
Prieto-Botella D, Martens DS, Valera-Gran D, Subiza-Pérez M, Tardón A, Lozano M, Casas M, Bustamante M, Jimeno-Romero A, Fernández-Somoano A, Llop S, Vrijheid M, Nawrot TS, Navarrete-Muñoz EM. Sedentary Behaviour and Telomere Length Shortening during Early Childhood: Evidence from the Multicentre Prospective INMA Cohort Study. Int J Environ Res Public Health. 2023 Mar 14;20(6):5134. PMID: 36982042
Prenatal and child vitamin D levels and allergy and asthma in childhood
Sangüesa J, Sunyer J, Garcia-Esteban R, Abellan A, Esplugues A, Garcia-Aymerich J, Guxens M, Irizar A, Júlvez J, Luque-García L, Rodríguez-Dehli AC, Tardón A, Torrent M, Vioque J, Vrijheid M, Casas M. Prenatal and child vitamin D levels and allergy and asthma in childhood. Pediatr Res. 2023 May;93(6):1745-1751. PMID: 36057646
Association between mediterranean diet and metal(loid) exposure in 4-5-year-old children living in Spain
Notario-Barandiaran L, Irizar A, Begoña-Zubero M, Soler-Blasco R, Riutort-Mayol G, Fernández-Somoano A, Tardón A, Casas M, Vrijheid M, Meharg A, Carey M, Meharg C, Ralphs K, McCreanor C, Grimalt JO, Vioque J, Signes-Pastor AJ. Association between mediterranean diet and metal(loid) exposure in 4-5-year-old children living in Spain. Environ Res. 2023 Sep 15;233:116508. PMID: 37392824
Cardiovascular risk factors and its patterns of change between 4 and 8 years of age in the INMA-Asturias cohort
Fernández-Iglesias R, Fernández-Somoano A, Rodríguez-Dehli C, Venta-Obaya R, Riaño-Galán I, Tardón A. Cardiovascular risk factors and its patterns of change between 4 and 8 years of age in the INMA-Asturias cohort. PLoS One. 2023 Apr 12;18(4):e0283799. PMID: 37043453
Children who sleep more may have longer telomeres: evidence from a longitudinal population study in Spain
Petermann-Rocha F, Valera-Gran D, Fernández-Pires P, Martens DS, Júlvez J, Rodríguez-Dehli C, Andiarena A, Lozano M, Fernández-Somoano A, Lertxundi A, Llop S, Guxens M, Nawrot TS, Navarrete-Muñoz EM. Children who sleep more may have longer telomeres: evidence from a longitudinal population study in Spain. Pediatr Res. 2023 Apr;93(5):1419-1424. PMID: 35974160
Childhood exposure to non-persistent pesticides and pubertal development in Spanish girls and boys: Evidence from the INMA (Environment and Childhood) cohort
Castiello F, Suárez B, Beneito A, Lopez-Espinosa MJ, Santa-Marina L, Lertxundi A, Tardón A, Riaño-Galán I, Casas M, Vrijheid M, Olea N, Fernández MF, Freire C. Childhood exposure to non-persistent pesticides and pubertal development in Spanish girls and boys: Evidence from the INMA (Environment and Childhood) cohort. Environ Pollut. 2023 Jan 1;316(Pt 2):120571. PMID: 36356884
Associations of residential greenspace exposure and fetal growth across four areas in Spain
Torres Toda M, Estarlich M, Ballester F, De Castro M, Fernández-Somoano A, Ibarluzea J, Iñiguez C, Lertxundi A, Subiza-Perez M, Sunyer J, Tardón A, Foraster M, Dadvand P. Associations of residential greenspace exposure and fetal growth across four areas in Spain. Health Place. 2022 Nov;78:102912. PMID: 36182749
Arsenic exposure and respiratory outcomes during childhood in the INMA study
Signes-Pastor AJ, Díaz-Coto S, Martinez-Camblor P, Carey M, Soler-Blasco R, García-Villarino M, Fernández-Somoano A, Julvez J, Carrasco P, Lertxundi A, Santa Marina L, Casas M, Meharg AA, Karagas MR, Vioque-Lopez J. Arsenic exposure and respiratory outcomes during childhood in the INMA study. PLoS One. 2022 Sep 9;17(9):e0274215. PMID: 36083997
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