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INMA: “Socioeconomic position, family context, and child cognitive development”

A new study of the Gipuzkoa and Valencia cohorts of the INMA study reflects how socioeconomic position (especially social class) and family context (especially cognitive stimulation, stress management and parental profile) are related to lower scores on the test that evaluates cognitive development.

Cognitive development is the growth and maturation of thought processes. It is a continuous evolution that, according to the developmental psychology of Jean Piaget, begins with the sensorimotor stage (from birth to approximately 2 years of age) and ends with the formal operations stage (from 11 to 15-20 years), characterized by the beginning of abstract thinking and by the use and contrast of hypotheses. Socioeconomic position increases differences in children’s cognitive development. This has traditionally been estimated through social class, educational level or employment situation. In addition to the influence of socioeconomic position, events that occur within the family context in a stable basis could influence cognitive development, such as the habit of eating together sharing experiences, or relaxing with a story in bed before going to sleep.

The recently published work analyzed the role of socioeconomic position, measured through various indicators, in cognitive development evaluated between 7 and 11 years of age, studying the role of the family context as a potential mediator. Indicators of socioeconomic position were evaluated during pregnancy (family social class, parental education, employment and disposable income) and at 7 (Gipuzkoa) and 11 (Valencia) years (At Risk of Poverty or Social Exclusion (AROPE)). Family context and cognitive development were measured with the Haezi-Etxadi Family Assessment Scale 7-11 (HEFAS 7-11) and Raven’s Colored Progressive Matrices (Raven’s CPM), respectively.

The socioeconomic position variable that was best related to cognitive development was family social class, showing that those households belonging to lower social classes had children who obtained lower cognitive scores. The indicators of socioeconomic position were related to subscales of the family context, particularly those related to cognitive stimulation, stress of mothers and fathers, and raising children. This indicated that households with more disadvantaged positions also presented worse scores on the family context scales. In this study it was found that part of the relationship between social class and cognitive development was explained by the family context. When the subscales were taken into account separately, they influenced between 5 and 11% on the relationship, while the percentage was 12% when they were taken into account as a whole.

Both socioeconomic position and family context contribute to children’s cognitive development. Equalizing policies and positive parenting programs could contribute to improving the cognitive development of children

Reference: González L, Popovic M, Rebagliato M, Estarlich M, Moirano G, Barreto-Zarza F, Richiardi L, Arranz E, Santa-Marina L, Zugna D, Ibarluzea J, Pizzi C. Socioeconomic position, family context, and child cognitive development. Eur J Pediatr. 2024 Mar 14. doi: 10.1007/s00431-024-05482-x. Epub ahead of print.

Link to scientific article: https://link.springer.com/article/10.1007/s00431-024-05482-x


INMA: “Prenatal and child vitamin D levels and allergy and asthma in childhood”

An INMA study shows that having higher vitamin D levels at pre-school age might be related with a lower chance of eczema in childhood. A recent study by Sangüesa et al. used data from the INMA-Asturias, Gipuzkoa, Menorca, Sabadell, and Valencia cohorts to evaluate the relationship between vitamin D levels and allergy and asthma in childhood.

The prevalence of vitamin D deficiency can be up to 75% in adults, even in Southern European countries where there is a lot of sunshine. Pregnant women and infants in particular are at an increased risk. Vitamin D is important for the development of the immune system, and a deficiency can be linked to allergy and asthma in childhood. While most previous studies only look at allergic and asthma symptoms at one time point, this study goes a step further by examining the effect of vitamin D levels during both pregnancy and childhood.

The current investigation used information on vitamin D levels recorded during the INMA study, during pregnancy for around 2500 participants and at 4 years of childhood for around 800 participants. Answers from questionnaires collected between 1 to 9 years were used to determine whether the child had: allergic rhinitis, atopic eczema, wheeze, and/or asthma.

Around 19% of mothers and 24% of children had a vitamin D deficiency. The study concluded that having a higher vitamin D level at a pre-school age was associated with a smaller chance of having eczema during childhood. Also, having a higher vitamin D level during pregnancy and childhood might lower the chance of late-onset wheezing.

The study builds on existing literature relating to the possible positive effect of vitamin D levels in children of pre-school age on atopic eczema. This could be because vitamin D plays a role in preventing inflammation responses and infections. However, the authors highlight the importance of further studies to evaluate vitamin D levels during pregnancy and childhood, and their relationship with allergic and asthma symptoms later in childhood.

Reference: Sangüesa J, Sunyer J, Garcia-Esteban R, Abellan A, Esplugues A, Garcia-Aymerich J, Guxens M, Irizar A, Júlvez J, Luque-García L, Rodríguez-Dehli AC, Tardón A, Torrent M, Vioque J, Vrijheid M, Casas M. Prenatal and child vitamin D levels and allergy and asthma in childhood. Pediatr Res. 2023 May;93(6):1745-1751.

Link to scientific article: https://pubmed.ncbi.nlm.nih.gov/36057646/


Exposome -
Exposome -


Beyond the single-outcome approach: A comparison of outcome-wide analysis methods for exposome research

Anguita-Ruiz A, Amine I, Stratakis N, Maitre L, Julvez J, Urquiza J, Luo C, Nieuwenhuijsen M, Thomsen C, Grazuleviciene R, Heude B, McEachan R, Vafeiadi M, Chatzi L, Wright J, Yang TC, Slama R, Siroux V, Vrijheid M, Basagaña X. Beyond the single-outcome approach: A comparison of outcome-wide analysis methods for exposome research. Environ Int. 2023 Dec;182:108344. PMID: 38016387


Exposome -
Exposome -


Statistical Approaches to Study Exposome-Health Associations in the Context of Repeated Exposure Data: A Simulation Study

Warembourg C, Anguita-Ruiz A, Siroux V, Slama R, Vrijheid M, Richiardi L, Basagaña X. Statistical Approaches to Study Exposome-Health Associations in the Context of Repeated Exposure Data: A Simulation Study. Environ Sci Technol. 2023 Oct 31;57(43):16232-16243. PMID: 37844068
Correction: Statistical Approaches to Study Exposome-Health Associations in the Context of Repeated Exposure Data: A Simulation Study. Environ Sci Technol. 2024 Jan 30;58(4):2162. PMID: 38227446


Built environment and Greeness -
Entorno urbano y Verdor -
Neurodevelopment -
Neurodevelopment -


Availability, accessibility, and use of green spaces and cognitive development in primary school children

Fernandes A, Krog NH, McEachan R, Nieuwenhuijsen M, Julvez J, Márquez S, de Castro M, Urquiza J, Heude B, Vafeiadi M, Gražulevičienė R, Slama R, Dedele A, Aasvang GM, Evandt J, Andrusaityte S, Kampouri M, Vrijheid M. Availability, accessibility, and use of green spaces and cognitive development in primary school children. Environ Pollut. 2023 Oct 1;334:122143. PMID: 37423460


Epigenetics -
Epigenetics -


Epimutation detection in the clinical context: guidelines and a use case from a new Bioconductor package

Ruiz-Arenas C, Abarrategui L, Hernandez-Ferrer C, Escribà-Montagut X, Pelegrí-Sisó D, Ryser-Welch P, Vrijheid M, Bustamante M, Grazuleviciene R, Lepeule J, Mathai M, Vafeiadi M, Beltran S, Pérez-Jurado LA, González JR. Epimutation detection in the clinical context: guidelines and a use case from a new Bioconductor package. Epigenetics. 2023 Dec;18(1):2230670. PMID: 37409354


Epigenetics -
Epigenetics -
Neurodevelopment -
Neurodevelopment -


Blood miRNA levels associated with ADHD traits in children across six European birth cohorts

Dypås LB, Duale N, Olsen AK, Bustamante M, Maitre L, Escaramis G, Julvez J, Aguilar-Lacasaña S, Andrusaityte S, Casas M, Vafeiadi M, Grazuleviciene R, Heude B, Lepeule J, Urquiza J, Wright J, Yang TC, Vrijheid M, Gützkow KB. Blood miRNA levels associated with ADHD traits in children across six European birth cohorts. BMC Psychiatry. 2023 Sep 25;23(1):696. PMID: 37749515


Epigenetics -
Epigenetics -
Nutrition -
Nutrition -
Reproductive health -
Reproductive health -


Maternal caffeine consumption during pregnancy and offspring cord blood DNA methylation: an epigenome-wide association study meta-analysis

Schellhas L, Monasso GS, Felix JF, Jaddoe VW, Huang P, Fernández-Barrés S, Vrijheid M, Pesce G, Annesi-Maesano I, Page CM, Brantsæter AL, Bekkhus M, Håberg SE, London SJ, Munafò MR, Zuccolo L, Sharp GC. Maternal caffeine consumption during pregnancy and offspring cord blood DNA methylation: an epigenome-wide association study meta-analysis. Epigenomics. 2023 Nov;15(22):1179-1193. PMID: 38018434


Genetics -
Genetics -
Metals -
Metals -


Genome-Wide Association Study of Blood Mercury in European Pregnant Women and Children

Dack K, Bustamante M, Taylor CM, Llop S, Lozano M, Yousefi P, Gražulevičienė R, Gutzkow KB, Brantsæter AL, Mason D, Escaramís G, Lewis SJ. Genome-Wide Association Study of Blood Mercury in European Pregnant Women and Children. Genes (Basel). 2023 Nov 24;14(12):2123. PMID: 38136945


Neurodevelopment -
Neurodevelopment -
Reproductive health -
Reproductive health -


Association between relative age at school and persistence of ADHD in prospective studies: an individual participant data meta-analysis

Synergy for the Influence of the Month of Birth in ADHD (SIMBA) study group. Association between relative age at school and persistence of ADHD in prospective studies: an individual participant data meta-analysis. Lancet Psychiatry. 2023 Dec;10(12):922-933. PMID: 37898142


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