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Children who sleep more may have longer telomeres: evidence from a longitudinal population study in Spain
Petermann-Rocha F, Valera-Gran D, Fernández-Pires P, Martens DS, Júlvez J, Rodríguez-Dehli C, Andiarena A, Lozano M, Fernández-Somoano A, Lertxundi A, Llop S, Guxens M, Nawrot TS, Navarrete-Muñoz EM. Children who sleep more may have longer telomeres: evidence from a longitudinal population study in Spain. Pediatr Res. 2023 Apr;93(5):1419-1424. PMID: 35974160
Kisspeptin as potential biomarker of environmental chemical mixture effect on reproductive hormone profile: A pilot study in adolescent males
Rodriguez-Carrillo A, Remy S, D’Cruz SC, Salamanca-Fernandez E, Gil F, Olmedo P, Mustieles V, Vela-Soria F, Baken K, Olea N, Smagulova F, Fernandez MF, Freire C. Kisspeptin as potential biomarker of environmental chemical mixture effect on reproductive hormone profile: A pilot study in adolescent males. Sci Total Environ. 2023 Apr 10;868:161668. PMID: 36657687
Childhood exposure to non-persistent pesticides and pubertal development in Spanish girls and boys: Evidence from the INMA (Environment and Childhood) cohort
Castiello F, Suárez B, Beneito A, Lopez-Espinosa MJ, Santa-Marina L, Lertxundi A, Tardón A, Riaño-Galán I, Casas M, Vrijheid M, Olea N, Fernández MF, Freire C. Childhood exposure to non-persistent pesticides and pubertal development in Spanish girls and boys: Evidence from the INMA (Environment and Childhood) cohort. Environ Pollut. 2023 Jan 1;316(Pt 2):120571. PMID: 36356884
INMA: “Short- and medium-term air pollution exposure, plasmatic protein levels and blood pressure in children”
Air pollution is one of the well-known key contributors to the global burden of mortality and disease. Nowadays, approximately 91% of the worldwide population lives in places where the levels of air quality exceed the guideline limits established by the WHO (World Health Organization, 2021). Among the different harmful air pollutants affecting human health, some have been highlighted given their potential direct effects in the incidence of cardiovascular disease; such as particulate matters (PMs) of different sizes (PM2.5 and PM10), nitrogen dioxide (NO2), sulphur dioxide (SO2), carbon monoxide (CO) and ozone (O3). According to recent evidences gathered in adults, the effects of these pollutants on cardiovascular health could be mediated through the elevation of blood pressure levels. However, not much is known about the exact underlying biological and molecular mechanisms. Additionally, evidence regarding to which extent the harmful effects of air pollutants on blood pressure levels occur during early stages of life is still scarce. On the other hand, this type of knowledge is of critical importance since exposure to environmental hazards during childhood might permanently change the body’s structure, metabolism, and physiology, marking the cardiovascular health of future populations. In order to shed some light to these open questions, INMA researchers have conducted what is one of the first studies evaluating the influence of air pollution exposure on blood pressure, and attempted to elucidate the most plausible biological mechanisms underlying such connections, all in the context of early childhood. To do so, different time windows of exposure to various air pollutants (1-day, 1-week, and 1-year) and the levels of thirty-six different cytokines, apolipoproteins, adipokines, and other proteins were measured in 1170 children aged 6–11 years (in which INMA represents one among five other cohorts), mapping their relationship with blood pressure alterations. Among the most remarkable results, they found a potential effect of exposure to some of the analyzed pollutants (NO2, PM10, or PM2.5) on the levels of proteins such as the hepatocyte growth factor (HGF) and interleukin 8 (IL8), showing higher concentrations in those children living in more polluted environments. These findings are in line with previous evidence in adults showing that the adverse health effects of air pollution could come from the exacerbation of harmful molecular processes such as oxidative stress and systemic inflammation. Interestingly, this study could further connect the exposure to NO2 with higher levels of systolic blood pressure, reaffirming in children what previous investigations have shown in adults. Furthermore, the mediation study suggested that HGF could explain 19% of the short-term effects of NO2 on blood pressure, thereby proposing specific molecular mechanisms that could underly the air pollutants-blood pressure relationship. Despite the interest and novelty of these results, they have to be interpreted with caution, since, for example, the relationship between HGF and BP is still uncertain. HGF is not usually considered as an inflammatory marker, and was first described as a liver-regenerative circulating factor. It could possibly be a downstream product of increased blood pressure or a molecule excreted by the body in response to air pollution exposure to counteract the endothelial damage induced by hypertension. In any case, further studies are needed to continue investigating these hypotheses. Overall, the findings presented in this study reinforce the idea of increased adverse cardiovascular effects as a result of air pollution exposure in children. Moreover, considering that elevated blood pressure during childhood has an impact on health across the lifespan, reducing the exposure to this environmental risk factor can be an important prevention strategy. INMA-article summary written by Augusto Anguita-Ruiz, INMA researcher. Reference: de Prado-Bert P, Warembourg C, Dedele A, Heude B, Borràs E, Sabidó E, Aasvang GM, Lepeule J, Wright J, Urquiza J, Gützkow KB, Maitre L, Chatzi L, Casas M, Vafeiadi M, Nieuwenhuijsen MJ, de Castro M, Grazuleviciene R, McEachan RRC, Basagaña X, Vrijheid M, Sunyer J, Bustamante M. Short- and medium-term air pollution exposure, plasmatic protein levels and blood pressure in children. Environ Res. 2022 Aug;211:113109. Link to scientific article: https://pubmed.ncbi.nlm.nih.gov/35292243/
Stroke genetics informs drug discovery and risk prediction across ancestries
Mishra A, Malik R, Hachiya T, Jürgenson T, Namba S, Posner DC, Kamanu FK, Koido M, Le Grand Q, Shi M, He Y, Georgakis MK, Caro I, Krebs K, Liaw YC, Vaura FC, Lin K, Winsvold BS, Srinivasasainagendra V, Parodi L, Bae HJ, Chauhan G, Chong MR, Tomppo L, Akinyemi R, Roshchupkin GV, Habib N, Jee YH, Thomassen JQ, Abedi V, Cárcel-Márquez J, Nygaard M, Leonard HL, Yang C, Yonova-Doing E, Knol MJ, Lewis AJ, Judy RL, Ago T, Amouyel P, Armstrong ND, Bakker MK, Bartz TM, Bennett DA, Bis JC, Bordes C, Børte S, Cain A, Ridker PM, Cho K, Chen Z, Cruchaga C, Cole JW, de Jager PL, de Cid R, Endres M, Ferreira LE, Geerlings MI, Gasca NC, Gudnason V, Hata J, He J, Heath AK, Ho YL, Havulinna AS, Hopewell JC, Hyacinth HI, Inouye M, Jacob MA, Jeon CE, Jern C, Kamouchi M, Keene KL, Kitazono T, Kittner SJ, Konuma T, Kumar A, Lacaze P, Launer LJ, Lee KJ, Lepik K, Li J, Li L, Manichaikul A, Markus HS, Marston NA, Meitinger T, Mitchell BD, Montellano FA, Morisaki T, Mosley TH, Nalls MA, Nordestgaard BG, O’Donnell MJ, Okada Y, Onland-Moret NC, Ovbiagele B, Peters A, Psaty BM, Rich SS, Rosand J, Sabatine MS, Sacco RL, Saleheen D, Sandset EC, Salomaa V, Sargurupremraj M, Sasaki M, Satizabal CL, Schmidt CO, Shimizu A, Smith NL, Sloane KL, Sutoh Y, Sun YV, Tanno K, Tiedt S, Tatlisumak T, Torres-Aguila NP, Tiwari HK, Trégouët DA, Trompet S, Tuladhar AM, Tybjærg-Hansen A, van Vugt M, Vibo R, Verma SS, Wiggins KL, Wennberg P, Woo D, Wilson PWF, Xu H, Yang Q, Yoon K; COMPASS Consortium; INVENT Consortium; Dutch Parelsnoer Initiative (PSI) Cerebrovascular Disease Study Group; Estonian Biobank; PRECISE4Q Consortium; FinnGen Consortium; NINDS Stroke Genetics Network (SiGN); MEGASTROKE Consortium; SIREN Consortium; China Kadoorie Biobank Collaborative Group; VA Million Veteran Program; International Stroke Genetics Consortium (ISGC); Biobank Japan; CHARGE Consortium; GIGASTROKE Consortium; Millwood IY, Gieger C, Ninomiya T, Grabe HJ, Jukema JW, Rissanen IL, Strbian D, Kim YJ, Chen PH, Mayerhofer E, Howson JMM, Irvin MR, Adams H, Wassertheil-Smoller S, Christensen K, Ikram MA, Rundek T, Worrall BB, Lathrop GM, Riaz M, Simonsick EM, Kõrv J, França PHC, Zand R, Prasad K, Frikke-Schmidt R, de Leeuw FE, Liman T, Haeusler KG, Ruigrok YM, Heuschmann PU, Longstreth WT, Jung KJ, Bastarache L, Paré G, Damrauer SM, Chasman DI, Rotter JI, Anderson CD, Zwart JA, Niiranen TJ, Fornage M, Liaw YP, Seshadri S, Fernández-Cadenas I, Walters RG, Ruff CT, Owolabi MO, Huffman JE, Milani L, Kamatani Y, Dichgans M, Debette S. Stroke genetics informs drug discovery and risk prediction across ancestries. Nature. 2022 Nov;611(7934):115-123. PMID: 36180795
A genome-wide association study of total child psychiatric problems scores
Neumann A, Nolte IM, Pappa I, Ahluwalia TS, Pettersson E, Rodriguez A, Whitehouse A, van Beijsterveldt CEM, Benyamin B, Hammerschlag AR, Helmer Q, Karhunen V, Krapohl E, Lu Y, van der Most PJ, Palviainen T, St Pourcain B, Seppälä I, Suarez A, Vilor-Tejedor N, Tiesler CMT, Wang C, Wills A, Zhou A, Alemany S, Bisgaard H, Bønnelykke K, Davies GE, Hakulinen C, Henders AK, Hyppönen E, Stokholm J, Bartels M, Hottenga JJ, Heinrich J, Hewitt J, Keltikangas-Järvinen L, Korhonen T, Kaprio J, Lahti J, Lahti-Pulkkinen M, Lehtimäki T, Middeldorp CM, Najman JM, Pennell C, Power C, Oldehinkel AJ, Plomin R, Räikkönen K, Raitakari OT, Rimfeld K, Sass L, Snieder H, Standl M, Sunyer J, Williams GM, Bakermans-Kranenburg MJ, Boomsma DI, van IJzendoorn MH, Hartman CA, Tiemeier H. A genome-wide association study of total child psychiatric problems scores. PLoS One. 2022 Aug 22;17(8):e0273116. PMID: 35994476
Pyrethroids and developmental neurotoxicity – A critical review of epidemiological studies and supporting mechanistic evidence
Andersen HR, David A, Freire C, Fernández MF, D’Cruz SC, Reina-Pérez I, Fini JB, Blaha L. Pyrethroids and developmental neurotoxicity – A critical review of epidemiological studies and supporting mechanistic evidence. Environ Res. 2022 Nov;214(Pt 2):113935. PMID: 35870501
Associations of residential greenspace exposure and fetal growth across four areas in Spain
Torres Toda M, Estarlich M, Ballester F, De Castro M, Fernández-Somoano A, Ibarluzea J, Iñiguez C, Lertxundi A, Subiza-Perez M, Sunyer J, Tardón A, Foraster M, Dadvand P. Associations of residential greenspace exposure and fetal growth across four areas in Spain. Health Place. 2022 Nov;78:102912. PMID: 36182749
Unravelling sex-specific BPA toxicokinetics in children using a pediatric PBPK model
Deepika D, Sharma RP, Schuhmacher M, Sakhi AK, Thomsen C, Chatzi L, Vafeiadi M, Quentin J, Slama R, Grazuleviciene R, Andrušaitytė S, Waiblinger D, Wright J, Yang TC, Urquiza J, Vrijheid M, Casas M, Domingo JL, Kumar V. Unravelling sex-specific BPA toxicokinetics in children using a pediatric PBPK model. Environ Res. 2022 Dec;215(Pt 1):114074. PMID: 35995217.
Maternal iron status during pregnancy and attention deficit/hyperactivity disorder symptoms in 7-year-old children: a prospective cohort study
Díaz-López A, Canals-Sans J, Julvez J, Fernandez-Barrés S, Llop S, Rebagliato M, Lertxundi N, Santa-Marina L, Guxens M, Sunyer J, Arija V. Maternal iron status during pregnancy and attention deficit/hyperactivity disorder symptoms in 7-year-old children: a prospective cohort study. Sci Rep. 2022 Dec 1;12(1):20762. PMID: 36456588.
Author Correction: Maternal iron status during pregnancy and attention deficit/hyperactivity disorder symptoms in 7-year-old children: a prospective cohort study. Sci Rep. 2023 Jan 18;13(1):993. PMID: 36653394
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