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The Marató TV3 awards 3 certificates to INMA Project
Yesterday 21 November on the studio nº1 of TV3 took place the award ceremony of the research grants of the Marató 2023: ‘Sexual and reproductive health’. The INMA Project was awarded 3 certificates in recognition of the support granted for its participation in the project entitled ‘Impact of the environment (exposome) on sexual and reproductive health in a national multicentre birth cohort’ which has a funding of 400,000 €. A great SUCCESS. Many thanks to all the volunteers of the INMA Project, whose data make it possible for the research to continue! 
INMA: “New study links air pollution to lower vitamin D levels during pregnancy”
A recent study, which analyzed data from multiple cohort studies across Europe and the United States, including the Spanish INMA project, has found that exposure to air pollution may lead to lower vitamin D levels in pregnant women. Specifically, the study highlighted the effects of fine particulate matter of less than 2.5 micrometers in diameter, known as PM2.5. Maintaining adequate vitamin D levels during pregnancy is crucial for both the mother and the developing baby. Insufficient vitamin D has been associated with pregnancy complications, as well as potential long-term impacts on a child’s health, affecting bone density, dental health, and cognitive development. Pregnant women can boost their vitamin D levels through sunlight exposure or by taking supplements. Previous studies have suggested that air pollutants, such as PM2.5, PM10, or NO2, could interfere with vitamin D production by blocking ultraviolet B (UVB) rays from reaching the skin or altering the body’s ability to metabolize the vitamin. While these mechanisms are suspected, it is still unclear at what level air pollution levels may significantly impact vitamin D levels in pregnant women. Study details and findings To explore this potential link, researchers gathered data from 15,935 pregnant women participating in five large cohort studies: the Amsterdam Born Children and their Development (ABCD) and Generation R studies based in the Netherlands, the Born in Bradford study based in England, the Project Viva study from the United States, and the INfancia y Medio Ambiente (INMA) study based in Spain. The study included women from four INMA regions: Asturias, Gipuzkoa, Sabadell, and Valencia. Air pollution exposure was measured at the participants’ home addresses, with the main analyses focusing on nitrogen dioxide (NO2) and PM2.5. Vitamin D levels were analyzed from blood samples taken during early or mid-pregnancy. The researchers also considered various factors that could affect vitamin D levels, such as maternal age, ethnicity, and socioeconomic status. The study revealed that higher exposure to PM2.5 was linked to a greater likelihood of suboptimal vitamin D levels in pregnant women. This relationship was particularly strong in the cohorts from Bradford in England and Sabadell in Spain. Importantly, these findings emerged even at levels of air pollution much lower than those seen in previous studies from different regions, such as China. The researchers noted differences in results between the cohorts and proposed that this could be due to variations in how air pollution was measured and the differences in composition of particulate matter in different regions. They also pointed out that previous studies had found links between larger particulate matter (PM10) and vitamin D levels, but this study did not replicate those findings. Future research and conclusion The authors emphasized the need for further research to understand other factors that could influence the link between air pollution and vitamin D, such as time spent outdoors, skin pigmentation and supplement use. They also acknowledged a limitation in their study: while pollution exposure at home was measured, the study did not account for time women may have spent in other environments. This study found a significant association between exposure to PM2.5 and lower vitamin D levels in pregnant women. Given that vitamin D plays an essential role in the healthy development of children, the authors highlight the importance of reducing air pollution exposure as a potential public health priority for pregnant women. Reference: Binter AC, Ghassabian A, Zou R, El Marroun H, Lertxundi A, Switkowski KM, Estarlich M, Rodríguez-Dehli AC, Esplugues A, Vrijkotte T, Sunyer J, Santa-Marina L, Fernández-Somoano A, Polanska K, McEachan RRC, Oken E, Tiemeier H, Guxens M. Associations of gestational exposure to air pollution with maternal vitamin D levels: a meta-analysis. J Clin Endocrinol Metab. 2024 Jun 13:dgae395. doi: 10.1210/clinem/dgae395. Epub ahead of print. PMID: 38870315. Link to the scientific article: https://doi.org/10.1210/clinem/dgae395
INMA-Menorca, our pioneer cohort
Last week Dr. Mònica Guxens, director of the INMA Project, and Susana Gros, Project Manager of the INMA Project, visited the INMA-Menorca cohort where a new follow-up visit is currently ongoing coordinated by Dr. Maties Torrent. And nothing would be possible without the support of Felix Vinent and the field workers, Lidia Naharro and Helena Pelegrí! INMA Menorca’s volunteers are already 27 years old!!! Our most sincere thanks to the more than 250 volunteers of this cohort who continue to collaborate with us.
Exposure to noise at home, emotional behaviour, and attention deficit hyperactivity disorder in 9-year-old children
Alfanjarín Monfort I, Rebagliato M, Estarlich M, Cases A, Ballester F, Llop S, López-Espinosa MJ, González L. [Exposure to noise at home, emotional behaviour, and attention deficit hyperactivity disorder in 9-year-old children]. An Sist Sanit Navar. 2024 Aug 29;47(2):e1079. Spanish. PMID: 39223960
Physical activity, sedentary behaviour, and childhood asthma: a European collaborative analysis
Eijkemans M, Mommers M, Harskamp-van Ginkel MW, Vrijkotte TGM, Ludvigsson J, Faresjö Å, Bergström A, Ekström S, Grote V, Koletzko B, Bønnelykke K, Eliasen AU, Bager P, Melbye M, Annesi-Maesano I, Baïz N, Barros H, Santos AC, Duijts L, Mensink-Bout SM, Flexeder C, Koletzko S, Schikowski T, Eggesbø MÅ, Lenters V, Fernández-Tardón G, Subiza-Perez M, Garcia-Aymerich J, López-Vicente M, Sunyer J, Torrent M, Ballester F, Kelleher C, Mehegan J, Berg AV, Herberth G, Standl M, Kuehni CE, Pedersen ESL, Jansen M, Gehring U, Boer JMA, Devereux G, Turner S, Peltola V, Lagström H, Inskip HM, Pike KC, Dalmeijer GW, Ent CKV, Thijs C. Physical activity, sedentary behaviour, and childhood asthma: a European collaborative analysis. BMJ Open Respir Res. 2024 Aug 15;11(1):e001630. PMID: 39147399
Common genetic variants associated with urinary phthalate levels in children: A genome-wide study
Bustamante M, Balagué-Dobón L, Buko Z, Sakhi AK, Casas M, Maitre L, Andrusaityte S, Grazuleviciene R, Gützkow KB, Brantsæter AL, Heude B, Philippat C, Chatzi L, Vafeiadi M, Yang TC, Wright J, Hough A, Ruiz-Arenas C, Nurtdinov RN, Escaramís G, González JR, Thomsen C, Vrijheid M. Common genetic variants associated with urinary phthalate levels in children: A genome-wide study. Environ Int. 2024 Aug;190:108845. PMID: 38945087
A Pregnancy and Childhood Epigenetics Consortium (PACE) meta-analysis highlights potential relationships between birth order and neonatal blood DNA methylation
Li S, Spitz N, Ghantous A, Abrishamcar S, Reimann B, Marques I, Silver MJ, Aguilar-Lacasaña S, Kitaba N, Rezwan FI, Röder S, Sirignano L, Tuhkanen J, Mancano G, Sharp GC, Metayer C, Morimoto L, Stein DJ, Zar HJ, Alfano R, Nawrot T, Wang C, Kajantie E, Keikkala E, Mustaniemi S, Ronkainen J, Sebert S, Silva W, Vääräsmäki M, Jaddoe VWV, Bernstein RM, Prentice AM, Cosin-Tomas M, Dwyer T, Håberg SE, Herceg Z, Magnus MC, Munthe-Kaas MC, Page CM, Völker M, Gilles M, Send T, Witt S, Zillich L, Gagliardi L, Richiardi L, Czamara D, Räikkönen K, Chatzi L, Vafeiadi M, Arshad SH, Ewart S, Plusquin M, Felix JF, Moore SE, Vrijheid M, Holloway JW, Karmaus W, Herberth G, Zenclussen A, Streit F, Lahti J, Hüls A, Hoang TT, London SJ, Wiemels JL. A Pregnancy and Childhood Epigenetics Consortium (PACE) meta-analysis highlights potential relationships between birth order and neonatal blood DNA methylation. Commun Biol. 2024 Jan 9;7(1):66. PMID: 38195839
Integrating multiple lines of evidence to assess the effects of maternal BMI on pregnancy and perinatal outcomes
Borges MC, Clayton GL, Freathy RM, Felix JF, Fernández-Sanlés A, Soares AG, Kilpi F, Yang Q, McEachan RRC, Richmond RC, Liu X, Skotte L, Irizar A, Hattersley AT, Bodinier B, Scholtens DM, Nohr EA, Bond TA, Hayes MG, West J, Tyrrell J, Wright J, Bouchard L, Murcia M, Bustamante M, Chadeau-Hyam M, Jarvelin MR, Vrijheid M, Perron P, Magnus P, Gaillard R, Jaddoe VWV, Lowe WL Jr, Feenstra B, Hivert MF, Sørensen TIA, Håberg SE, Serbert S, Magnus M, Lawlor DA. Integrating multiple lines of evidence to assess the effects of maternal BMI on pregnancy and perinatal outcomes. BMC Med. 2024 Jan 29;22(1):32. PMID: 38281920
Associations of gestational exposure to air pollution with maternal vitamin D levels: a meta-analysis
Binter AC, Ghassabian A, Zou R, El Marroun H, Lertxundi A, Switkowski KM, Estarlich M, Rodríguez-Dehli AC, Esplugues A, Vrijkotte T, Sunyer J, Santa-Marina L, Fernández-Somoano A, Polanska K, McEachan RRC, Oken E, Tiemeier H, Guxens M. Associations of gestational exposure to air pollution with maternal vitamin D levels: a meta-analysis. J Clin Endocrinol Metab. 2024 Jun 13:dgae395. doi: 10.1210/clinem/dgae395. Epub ahead of print. PMID: 38870315
Estimating the dynamic early life exposure to PFOA and PFOS of the HELIX children: Emerging profiles via prenatal exposure, breastfeeding, and diet
Ratier A, Casas M, Grazuleviciene R, Slama R, Småstuen Haug L, Thomsen C, Vafeiadi M, Wright J, Zeman FA, Vrijheid M, Brochot C. Estimating the dynamic early life exposure to PFOA and PFOS of the HELIX children: Emerging profiles via prenatal exposure, breastfeeding, and diet. Environ Int. 2024 Apr;186:108621. PMID: 38593693
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