Valencia
In October 2003 the pilot study for the creation of the INMA cohort in Valencia was carried out. In February 2004 started the recruitment of the cohort that went on until June 2005. 855 women that belonged to the departments of health 6 (34 municipalities) and 7 (two quarters of Valencia) were recruited. They were selected by consecutive sampling of among all those of the area of study that went to the population sieving of the syndrome of Down that is carried out among the 10-13 weeks of gestation in the Hospital de la Fe, reference hospital of the area, and who complied with the inclusion criteria: (1) To be at least 16 years; (2) To be in the week 10-13 of gestation; (3) to have a unique pregnancy; (4) To have the intention of continuing the follow-up and delivering in the corresponding centres of reference; (5) Not to have any impediment for the communication and (6) Not to suffer any chronic disease prior to the pregnancy.
During the pregnancy the follow-up was carried out at weeks 12 and 32. In these follow-ups, biological samples were obtained (blood, nail and urine) and also data related to diet, jobs of the progenitors and exposure to pollutants.
The newborns were followed along the childhood. A visit was made when they were 1 year, in which the neurological development, the anthropometry, the respiratory health, the diet and the environmental exposures were measured and studied. Moreover, the levels of atmospheric pollutants were measured in the homes (in and outside) of half of the children; in order to make this, dosimeters were installed for 15 days at their homes. At 2 years, a telephonic interview was made, and at 4 years they were appointed to go to the Hospital de la Fe in order to evaluate their dietary habits, their growth and to be able to obtain biological samples (urine, hair and blood) to measure nutrients and exposure to environmental pollutants.
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Collaborating Entities:
Buscador
Maternal occupational exposure to chemicals and child cognitive function
Ish J, Symanski E, Gimeno Ruiz de Porras D, Casas M, Delclos GL, Guxens M, Ibarluzea JM, Iñiguez C, Lertxundi A, Rebagliato M, Swartz MD, Whitworth KW. Maternal occupational exposure to chemicals and child cognitive function. Pediatr Res. 2022 Oct;92(4):1153-1160. PMID: 35578010
Correction: Maternal occupational exposure to chemicals and child cognitive function. Pediatr Res. 2023 Jan;93(1):278-279. PMID: 36138064
Association of prenatal phthalate exposure with pubertal development in Spanish boys and girls
Freire C, Castiello F, Lopez-Espinosa MJ, Beneito A, Lertxundi A, Jimeno-Romero A, Vrijheid M, Casas M. Association of prenatal phthalate exposure with pubertal development in Spanish boys and girls. Environ Res. 2022 Oct;213:113606. PMID: 35716812
Association between maternal thyroid function and risk of gestational hypertension and pre-eclampsia: a systematic review and individual-participant data meta-analysis
Toloza FJK, Derakhshan A, Männistö T, Bliddal S, Popova PV, Carty DM, Chen L, Taylor P, Mosso L, Oken E, Suvanto E, Itoh S, Kishi R, Bassols J, Auvinen J, López-Bermejo A, Brown SJ, Boucai L, Hisada A, Yoshinaga J, Shilova E, Grineva EN, Vrijkotte TGM, Sunyer J, Jiménez-Zabala A, Riaño-Galan I, Lopez-Espinosa MJ, Prokop LJ, Singh Ospina N, Brito JP, Rodriguez-Gutierrez R, Alexander EK, Chaker L, Pearce EN, Peeters RP, Feldt-Rasmussen U, Guxens M, Chatzi L, Delles C, Roeters van Lennep JE, Pop VJM, Lu X, Walsh JP, Nelson SM, Korevaar TIM, Maraka S. Association between maternal thyroid function and risk of gestational hypertension and pre-eclampsia: a systematic review and individual-participant data meta-analysis. Lancet Diabetes Endocrinol. 2022 Apr;10(4):243-252. PMID: 35255260
Household income, fetal size and birth weight: an analysis of eight populations
Turner S, Posthumus AG, Steegers EAP, AlMakoshi A, Sallout B, Rifas-Shiman SL, Oken E, Kumwenda B, Alostad F, Wright-Corker C, Watson L, Mak D, Cheung HC, Judge A, Aucott L, Jaddoe VWV, Annesi Maesano I, Soomro MH, Hindmarsh P, Jacobsen G, Vik T, Riaño-Galan I, Rodríguez-Dehli AC, Lertxundi A, Rodriguez LSM, Vrijheid M, Julvez J, Esplugues A, Iñiguez C. Household income, fetal size and birth weight: an analysis of eight populations. J Epidemiol Community Health. 2022 Jul;76(7):629-636. PMID: 35414519
Associations of early-life pet ownership with asthma and allergic sensitization: A meta-analysis of more than 77,000 children from the EU Child Cohort Network
Pinot de Moira A, Strandberg-Larsen K, Bishop T, Pedersen M, Avraam D, Cadman T, Calas L, Casas M, de Lauzon Guillain B, Elhakeem A, Esplugues A, Estarlich M, Foong RE, Haakma S, Harris JR, Huang RC, Inskip H, Lertxundi A, Mensink-Bout SM, Nader JLT, Pizzi C, Popovic M, Salika T, Sunyer J, Van Meel ER, Swertz MA, Jaddoe VWV, Burton P, Duijts L, Nybo Andersen AM. Associations of early-life pet ownership with asthma and allergic sensitization: A meta-analysis of more than 77,000 children from the EU Child Cohort Network. J Allergy Clin Immunol. 2022 Jul;150(1):82-92. PMID: 35150722
Early-life respiratory tract infections and the risk of school-age lower lung function and asthma: a meta-analysis of 150 000 European children
van Meel ER, Mensink-Bout SM, den Dekker HT, Ahluwalia TS, Annesi-Maesano I, Arshad SH, Baïz N, Barros H, von Berg A, Bisgaard H, Bønnelykke K, Carlsson CJ, Casas M, Chatzi L, Chevrier C, Dalmeijer G, Dezateux C, Duchen K, Eggesbø M, van der Ent C, Fantini M, Flexeder C, Frey U, Forastiere F, Gehring U, Gori D, Granell R, Griffiths LJ, Inskip H, Jerzynska J, Karvonen AM, Keil T, Kelleher C, Kogevinas M, Koppen G, Kuehni CE, Lambrechts N, Lau S, Lehmann I, Ludvigsson J, Magnus MC, Mélen E, Mehegan J, Mommers M, Andersen AN, Nystad W, Pedersen ESL, Pekkanen J, Peltola V, Pike KC, de Moira AP, Pizzi C, Polanska K, Popovic M, Porta D, Roberts G, Santos AC, Schultz ES, Standl M, Sunyer J, Thijs C, Toivonen L, Uphoff E, Usemann J, Vafeidi M, Wright J, de Jongste JC, Jaddoe VWV, Duijts L. Early-life respiratory tract infections and the risk of school-age lower lung function and asthma: a meta-analysis of 150 000 European children. Eur Respir J. 2022 Oct 6;60(4):2102395. PMID: 35487537
Measures of Early-life Behavior and Later Psychopathology in the LifeCycle Project – EU Child Cohort Network: A Cohort Description
Nader JL, López-Vicente M, Julvez J, Guxens M, Cadman T, Elhakeem A, Järvelin MR, Rautio N, Miettunen J, El Marroun H, Melchior M, Heude B, Charles MA, Yang TC, McEachan RRC, Wright J, Polanska K, Carson J, Lin A, Rauschert S, Huang RC, Popovic M, Richiardi L, Corpeleijn E, Cardol M, Mikkola TM, Eriksson JG, Salika T, Inskip H, Vinther JL, Strandberg-Larsen K, Gürlich K, Grote V, Koletzko B, Vafeiadi M, Sunyer J, Jaddoe VWV, Harris JR. Cohort description: Measures of early-life behaviour and later psychopathology in the LifeCycle Project – EU Child Cohort Network. J Epidemiol. 2023 Jun 5;33(6):321-331. PMID: 34776498
Serum metal levels in a population of Spanish pregnant women
Miren Begoña Zubero, Sabrina Llop, Amaia Irizar, Mario Murcia , Amaia Molinuevo, Ferrán Ballester , Michael Levi , Manuel Lozano , Mikel Ayerdi, Loreto Santa-Marina. Serum metal levels in a population of Spanish pregnant women. Gac Sanit. 2022 Sep-Oct;36(5):468-476. PMID: 34627659
Maternal Perfluoroalkyl Substances, Thyroid Hormones, and DIO Genes: A Spanish Cross-sectional Study
Sarzo B, Ballesteros V, Iñiguez C, Manzano-Salgado CB, Casas M, Llop S, Murcia M, Guxens M, Vrijheid M, Marina LS, Schettgen T, Espada M, Irizar A, Fernandez-Jimenez N, Ballester F, Lopez-Espinosa MJ. Maternal Perfluoroalkyl Substances, Thyroid Hormones, and DIO Genes: A Spanish Cross-sectional Study. Environ Sci Technol. 2024-2023-2022-2021 Jul 27. Online ahead of print. PMID: 34314170
Poverty, social exclusion, and mental health: the role of the family context in children aged 7-11 years INMA mother-and-child cohort study
González L, Estarlich M, Murcia M, Barreto-Zarza F, Santa-Marina L, Simó S, Larrañaga MI, Ruiz-Palomino E, Ibarluzea J, Rebagliato M. Poverty, social exclusion, and mental health: the role of the family context in children aged 7-11 years INMA mother-and-child cohort study. Eur Child Adolesc Psychiatry. 2023 Feb;32(2):235-248. PMID: 34312704
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