Valencia

In October 2003 the pilot study for the creation of the INMA cohort in Valencia was carried out. In February 2004 started the recruitment of the cohort that went on until June 2005. 855 women that belonged to the departments of health 6 (34 municipalities) and 7 (two quarters of Valencia) were recruited. They were selected by consecutive sampling of among all those of the area of study that went to the population sieving of the syndrome of Down that is carried out among the 10-13 weeks of gestation in the Hospital de la Fe, reference hospital of the area, and who complied with the inclusion criteria: (1) To be at least 16 years; (2) To be in the week 10-13 of gestation; (3) to have a unique pregnancy; (4) To have the intention of continuing the follow-up and delivering in the corresponding centres of reference; (5) Not to have any impediment for the communication and (6) Not to suffer any chronic disease prior to the pregnancy.

During the pregnancy the follow-up was carried out at weeks 12 and 32. In these follow-ups, biological samples were obtained (blood, nail and urine) and also data related to diet, jobs of the progenitors and exposure to pollutants.

The newborns were followed along the childhood. A visit was made when they were 1 year, in which the neurological development, the anthropometry, the respiratory health, the diet and the environmental exposures were measured and studied. Moreover, the levels of atmospheric pollutants were measured in the homes (in and outside) of half of the children; in order to make this, dosimeters were installed for 15 days at their homes. At 2 years, a telephonic interview was made, and at 4 years they were appointed to go to the Hospital de la Fe in order to evaluate their dietary habits, their growth and to be able to obtain biological samples (urine, hair and blood) to measure nutrients and exposure to environmental pollutants.

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325 Results

Metals -
Neurodevelopment -


Prenatal manganese serum levels and neurodevelopment at 4 years of age

Irizar A, Molinuevo A, Andiarena A, Jimeno-Romero A, San Román A, Broberg K, Llop S, Soler-Blasco R, Murcia M, Ballester F, Lertxundi A. Prenatal manganese serum levels and neurodevelopment at 4 years of age. Environ Res. 2021 Jun;197:111172. PMID: 33857462


Neurodevelopment -
Persistent organic compounds -


Prenatal perfluoroalkyl substance exposure and neuropsychological development throughout childhood: The INMA Project

Carrizosa C, Murcia M, Ballesteros V, Costa O, Manzano-Salgado CB, Ibarluzea J, Iñiguez C, Casas M, Andiarena A, Llop S, Lertxundi A, Schettgen T, Sunyer J, Ballester F, Vrijheid M, Lopez-Espinosa MJ. Prenatal perfluoroalkyl substance exposure and neuropsychological development throughout childhood: The INMA Project. J Hazard Mater. 2021 Aug 15;416:125185. PMID: 33882389


Family factors -
Neurodevelopment -


Family Context Assessment in Middle Childhood: A Tool Supporting Social, Educational, and Public Health Interventions

Barreto-Zarza F, Sánchez de Miguel M, Ibarluzea J, González-Safont L, Rebagliato M, Arranz-Freijo EB. Family Context Assessment in Middle Childhood: A Tool Supporting Social, Educational, and Public Health Interventions. Int J Environ Res Public Health. 2021 Jan 26;18(3):1094.
PMID: 33530634


Electromagnetics field -


Radiofrequency electromagnetic fields from mobile communication: Description of modeled dose in brain regions and the body in European children and adolescents

Birks LE, van Wel L, Liorni I, Pierotti L, Guxens M, Huss A, Foerster M, Capstick M, Eeftens M, El Marroun H, Estarlich M, Gallastegi M, Safont LG, Joseph W, Santa-Marina L, Thielens A, Torrent M, Vrijkotte T, Wiart J, Röösli M, Cardis E, Vermeulen R, Vrijheid M. Radiofrequency electromagnetic fields from mobile communication: Description of modeled dose in brain regions and the body in European children and adolescents. Environ Res. 2021 Feb;193:110505. PMID: 33245886


Electromagnetics field -
Neurodevelopment -


Association between estimated whole-brain radiofrequency electromagnetic fields dose and cognitive function in preadolescents and adolescents

Cabré-Riera A, van Wel L, Liorni I, Thielens A, Birks LE, Pierotti L, Joseph W, González-Safont L, Ibarluzea J, Ferrero A, Huss A, Wiart J, Santa-Marina L, Torrent M, Vrijkotte T, Capstick M, Vermeulen R, Vrijheid M, Cardis E, Röösli M, Guxens M. Association between estimated whole-brain radiofrequency electromagnetic fields dose and cognitive function in preadolescents and adolescents. Int J Hyg Environ Health. 2021 Jan;231:113659. doi: 10.1016/j.ijheh.2020.113659. Epub 2020 Nov 19. PMID: 33221634


Neurodevelopment -
Reproductive health -


Dietary inflammatory index of mothers during pregnancy and Attention Deficit-Hyperactivity Disorder symptoms in the child at preschool age: a prospective investigation in the INMA and RHEA cohorts

Lertxundi N, Molinuevo A, Valvi D, Gorostiaga A, Balluerka N, Shivappa N, Hebert J, Navarrete-Muñoz EM, Vioque J, Tardón A, Vrijheid M, Roumeliotaki T, Koutra K, Chatzi L, Ibarluzea J. Dietary inflammatory index of mothers during pregnancy and Attention Deficit-Hyperactivity Disorder symptoms in the child at preschool age: a prospective investigation in the INMA and RHEA cohorts. Eur Child Adolesc Psychiatry. 2022 Apr;31(4):615-624. PMID: 33398651


Metals -
Respiratory health and atopy -


Pre and postnatal exposure to mercury and respiratory health in preschool children from the Spanish INMA Birth Cohort Study

Carrasco P, Estarlich M, Iñiguez C, Ferrero A, Murcia M, Esplugues A, Vioque J, Marina LS, Zabaleta C, Iriarte G, Fernández-Somoano A, Tardon A, Vrijheid M, Sunyer J, Ballester F, Llop S. Pre and postnatal exposure to mercury and respiratory health in preschool children from the Spanish INMA Birth Cohort Study. Sci Total Environ. 2021 Aug 15;782:146654. PMID: 33838378


Pregnancy complications -
Reproductive health -


Maternal sleep duration and neonate birth weight: A population-based cohort study

Marinelli M, Carsin AE, Turner MC, Fernández-Somoano A, Rodriguez-Dehli AC, Basterrechea M, Santa-Marina L, Iñiguez C, Lopez-Espinosa MJ, Sunyer J, Julvez J. Maternal sleep duration and neonate birth weight: A population-based cohort study. Int J Gynaecol Obstet. 2022 Mar;156(3):494-501. PMID: 33754347


Neurodevelopment -
Nutrition -


The Use of Lower or Higher Than Recommended Doses of Folic Acid Supplements during Pregnancy Is Associated with Child Attentional Dysfunction at 4-5 Years of Age in the INMA Project

Compañ Gabucio LM, García de la Hera M, Torres Collado L, Fernández-Somoano A, Tardón A, Guxens M, Vrijheid M, Rebagliato M, Murcia M, Ibarluzea J, Martí I, Vioque J. The Use of Lower or Higher Than Recommended Doses of Folic Acid Supplements during Pregnancy Is Associated with Child Attentional Dysfunction at 4-5 Years of Age in the INMA Project. Nutrients. 2021 Jan 23;13(2):327. PMID: 33498619


Genetics -
Respiratory health and atopy -


Shared DNA methylation signatures in childhood allergy: The MeDALL study

Xu CJ, Gruzieva O, Qi C, Esplugues A, Gehring U, Bergström A, Mason D, Chatzi L, Porta D, Lodrup Carlsen KC, Baïz N, Madore AM, Alenius H, van Rijkom B, Jankipersadsing SA, van der Vlies P, Kull I, van Hage M, Bustamante M, Lertxundi A, Torrent M, Santorelli G, Fantini MP, Hovland V, Pesce G; BIOS Consortium, Fyhrquist N, Laatikainen T, Nawijn MC, Li Y, Wijmenga C, Netea MG, Bousquet J, Anto JM, Laprise C, Haahtela T, Annesi-Maesano I, Carlsen KH, Gori D, Kogevinas M, Wright J, Söderhäll C, Vonk JM, Sunyer J, Melén E, Koppelman GH. Shared DNA methylation signatures in childhood allergy: The MeDALL study. J Allergy Clin Immunol. 2021 Mar;147(3):1031-1040. PMID: 33338541


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