Gipuzkoa
In May 2006 the INMA project was set up in Gipuzkoa with the aim of evaluating the role of the environmental pollutants present in the air, water and diet in the growth and development of the children. The incorporation of the women to the cohort was made coinciding with the first echography of pregnancy control. Biological samples were taken (blood, urine, hair, placenta, etc.) and a series of questionnaires were complimented (general, diet, labour, environmental, etc.) to evaluate the impact of the environmental pollutants present in the air and the water of consumption, as well as an estimation of the polluting agents contributed by the diet.
The mothers were recruited from population visiting at the Hospital of Zumarraga, which includes the municipalities of the Goierri and the Alto and Medio Urola. They were selected of this area because of the characteristics of the services of the hospital and primary attention centre, as well as by the environmental characteristics: hard presence of metallurgical industry, high density of traffic, low levels of products derived from the disinfection in the consumption water and a rich diet in fish, together with certain degree of hypothyroidism in the pregnant women.
Since then, the pursuit of 640 women has been made in first and the third trimester of pregnancy. At the moment the pursuit is being made of 623 children in aspects of growth and neurobehavioural development.
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Funders of INMA-Gipuzkoa cohort:
This study was funded by grants from Instituto de Salud Carlos III (FIS-PI06/0867, FIS-PI09/00090, FIS-PI13/02187 and FIS-PI18/01142 incl. FEDER funds), CIBERESP, Department of Health of the Basque Government (2005111093, 2009111069, 2013111089 and 2015111065), and the Provincial Government of Gipuzkoa (DFG06/002, DFG08/001 and DFG15/221) and annual agreements with the municipalities of the study area (Zumarraga, Urretxu , Legazpi, Azkoitia y Azpeitia y Beasain).
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Collaborating Entities:
Buscador
Validation of a Parent-Reported Physical Activity Questionnaire by Accelerometry in European Children Aged from 6 to 12 Years Old
Prieto-Botella D, Valera-Gran D, Santa-Marina L, Babarro I, Subiza-Pérez M, Casas M, Guxens M, Cárdenas-Fuentes G, Heude B, Bernard JY, McEachan RRC, García-Aymerich J, Vrijheid M, Navarrete-Muñoz EM. Validation of a Parent-Reported Physical Activity Questionnaire by Accelerometry in European Children Aged from 6 to 12 Years Old. Int J Environ Res Public Health. 2022 Jul 27;19(15):9178. PMID: 35954544
Prenatal exposure to mixtures of phthalates and phenols and body mass index and blood pressure in Spanish preadolescents
Güil-Oumrait N, Cano-Sancho G, Montazeri P, Stratakis N, Warembourg C, Lopez-Espinosa MJ, Vioque J, Santa-Marina L, Jimeno-Romero A, Ventura R, Monfort N, Vrijheid M, Casas M. Prenatal exposure to mixtures of phthalates and phenols and body mass index and blood pressure in Spanish preadolescents. Environ Int. 2022 Nov;169:107527. PMID: 36126421
Do prepubertal hormones, 2D:4D index and psychosocial context jointly explain 11-year-old preadolescents’ involvement in bullying?
Babarro I, Andiarena A, Fano E, García-Baquero G, Lebeña A, Arranz-Freijo EB, Ibarluzea J. Do prepubertal hormones, 2D:4D index and psychosocial context jointly explain 11-year-old preadolescents’ involvement in bullying? Biol Psychol. 2022 Jul;172:108379. PMID: 35690279
Genetics of early-life head circumference and genetic correlations with neurological, psychiatric and cognitive outcomes
Vogelezang S, Bradfield JP; Early Growth Genetics Consortium, Grant SFA, Felix JF, Jaddoe VWV. Genetics of early-life head circumference and genetic correlations with neurological, psychiatric and cognitive outcomes. BMC Med Genomics. 2022 Jun 4;15(1):124. PMID: 35659227
Maternal occupational exposure to chemicals and child cognitive function
Ish J, Symanski E, Gimeno Ruiz de Porras D, Casas M, Delclos GL, Guxens M, Ibarluzea JM, Iñiguez C, Lertxundi A, Rebagliato M, Swartz MD, Whitworth KW. Maternal occupational exposure to chemicals and child cognitive function. Pediatr Res. 2022 Oct;92(4):1153-1160. PMID: 35578010
Correction: Maternal occupational exposure to chemicals and child cognitive function. Pediatr Res. 2023 Jan;93(1):278-279. PMID: 36138064
Association of prenatal phthalate exposure with pubertal development in Spanish boys and girls
Freire C, Castiello F, Lopez-Espinosa MJ, Beneito A, Lertxundi A, Jimeno-Romero A, Vrijheid M, Casas M. Association of prenatal phthalate exposure with pubertal development in Spanish boys and girls. Environ Res. 2022 Oct;213:113606. PMID: 35716812
Association between maternal thyroid function and risk of gestational hypertension and pre-eclampsia: a systematic review and individual-participant data meta-analysis
Toloza FJK, Derakhshan A, Männistö T, Bliddal S, Popova PV, Carty DM, Chen L, Taylor P, Mosso L, Oken E, Suvanto E, Itoh S, Kishi R, Bassols J, Auvinen J, López-Bermejo A, Brown SJ, Boucai L, Hisada A, Yoshinaga J, Shilova E, Grineva EN, Vrijkotte TGM, Sunyer J, Jiménez-Zabala A, Riaño-Galan I, Lopez-Espinosa MJ, Prokop LJ, Singh Ospina N, Brito JP, Rodriguez-Gutierrez R, Alexander EK, Chaker L, Pearce EN, Peeters RP, Feldt-Rasmussen U, Guxens M, Chatzi L, Delles C, Roeters van Lennep JE, Pop VJM, Lu X, Walsh JP, Nelson SM, Korevaar TIM, Maraka S. Association between maternal thyroid function and risk of gestational hypertension and pre-eclampsia: a systematic review and individual-participant data meta-analysis. Lancet Diabetes Endocrinol. 2022 Apr;10(4):243-252. PMID: 35255260
Household income, fetal size and birth weight: an analysis of eight populations
Turner S, Posthumus AG, Steegers EAP, AlMakoshi A, Sallout B, Rifas-Shiman SL, Oken E, Kumwenda B, Alostad F, Wright-Corker C, Watson L, Mak D, Cheung HC, Judge A, Aucott L, Jaddoe VWV, Annesi Maesano I, Soomro MH, Hindmarsh P, Jacobsen G, Vik T, Riaño-Galan I, Rodríguez-Dehli AC, Lertxundi A, Rodriguez LSM, Vrijheid M, Julvez J, Esplugues A, Iñiguez C. Household income, fetal size and birth weight: an analysis of eight populations. J Epidemiol Community Health. 2022 Jul;76(7):629-636. PMID: 35414519
Associations of early-life pet ownership with asthma and allergic sensitization: A meta-analysis of more than 77,000 children from the EU Child Cohort Network
Pinot de Moira A, Strandberg-Larsen K, Bishop T, Pedersen M, Avraam D, Cadman T, Calas L, Casas M, de Lauzon Guillain B, Elhakeem A, Esplugues A, Estarlich M, Foong RE, Haakma S, Harris JR, Huang RC, Inskip H, Lertxundi A, Mensink-Bout SM, Nader JLT, Pizzi C, Popovic M, Salika T, Sunyer J, Van Meel ER, Swertz MA, Jaddoe VWV, Burton P, Duijts L, Nybo Andersen AM. Associations of early-life pet ownership with asthma and allergic sensitization: A meta-analysis of more than 77,000 children from the EU Child Cohort Network. J Allergy Clin Immunol. 2022 Jul;150(1):82-92. PMID: 35150722
Early-life respiratory tract infections and the risk of school-age lower lung function and asthma: a meta-analysis of 150 000 European children
van Meel ER, Mensink-Bout SM, den Dekker HT, Ahluwalia TS, Annesi-Maesano I, Arshad SH, Baïz N, Barros H, von Berg A, Bisgaard H, Bønnelykke K, Carlsson CJ, Casas M, Chatzi L, Chevrier C, Dalmeijer G, Dezateux C, Duchen K, Eggesbø M, van der Ent C, Fantini M, Flexeder C, Frey U, Forastiere F, Gehring U, Gori D, Granell R, Griffiths LJ, Inskip H, Jerzynska J, Karvonen AM, Keil T, Kelleher C, Kogevinas M, Koppen G, Kuehni CE, Lambrechts N, Lau S, Lehmann I, Ludvigsson J, Magnus MC, Mélen E, Mehegan J, Mommers M, Andersen AN, Nystad W, Pedersen ESL, Pekkanen J, Peltola V, Pike KC, de Moira AP, Pizzi C, Polanska K, Popovic M, Porta D, Roberts G, Santos AC, Schultz ES, Standl M, Sunyer J, Thijs C, Toivonen L, Uphoff E, Usemann J, Vafeidi M, Wright J, de Jongste JC, Jaddoe VWV, Duijts L. Early-life respiratory tract infections and the risk of school-age lower lung function and asthma: a meta-analysis of 150 000 European children. Eur Respir J. 2022 Oct 6;60(4):2102395. PMID: 35487537
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